Neurodevelopment in early treated HIV‐infected infants participating in a developmental stimulation programme compared with controls.
Background: Neurodevelopmental stimulation programmes can improve developmental outcomes. Antiretroviral therapy (ART) started soon after birth potentially limits the invasion of HIV into the central nervous system. A combination of developmental stimulation and early ART initiation may reduce devel...
| Publicado en: | Child: Care, Health & Development Vol. 47; no. 2; pp. 154 - 163 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Mar2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=148454121&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 148454121 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03051862 6NX jtl: Child: Care, Health & Development issn: 03051862 maglogo: Y pubinfo: dt: Mar2021 vid: 47 iid: 2 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 148454121 148454121 148575985 148454121 10.1111/cch.12828 148454121 ppf: 154 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Neurodevelopment in early treated HIV‐infected infants participating in a developmental stimulation programme compared with controls. aug: au: Strehlau, Renate Burke, Megan Aswegen, Tamryn Kuhn, Louise Potterton, Joanne affil: Empilweni Services and Research Unit, Rahima Moosa Mother and Child Hospital, Department of Paediatrics and Child Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa sug: subj: HIV Infections Drug Therapy Anti-Retroviral Agents Therapeutic Use Early Childhood Intervention Methods Infant Stimulation Methods Neurodevelopment In Infancy and Childhood Program Evaluation Human Infant, Newborn Infant Child, Preschool South Africa Scales Motor Skills Evaluation Cognition Evaluation Outcome Assessment Infant, Newborn: birth-1 month Infant: 1-23 months Child, Preschool: 2-5 years ab: Background: Neurodevelopmental stimulation programmes can improve developmental outcomes. Antiretroviral therapy (ART) started soon after birth potentially limits the invasion of HIV into the central nervous system. A combination of developmental stimulation and early ART initiation may reduce developmental delays in children with perinatally acquired HIV infection. Methods: At a single site in Johannesburg, South Africa, we enrolled 36 HIV‐infected neonates on ART into an intervention group (IG) participating in a yearlong home‐based, neurodevelopmental stimulation programme. Bayley Scales of Infant and Toddler Development‐3rd Edition (BSID‐III) assessments were conducted at 12 months. Scores were compared with 24 early treated HIV‐infected infants in an observational group (OG). BSID‐III assessments were also conducted for older children in an OG at 24 or 36 months. Cognitive, language and motor scaled and composite scores were analysed. Results: BSID‐III scaled and composite scores were all higher in the IG apart from the gross motor scaled score (9.25 vs. 10, p = 0.1954). Receptive communication scaled score was significantly higher in the IG (10.96 vs. 9, p = 0.0331). IG composite scores were all higher than OG scores. OG children assessed at 24 or 36 months had lower composite scores in all subscales than 12‐month OG scores. Conclusions: Early treated HIV‐infected children participating in a neurodevelopmental stimulation programme achieved higher BSID‐III scores at 12 months compared with early treated HIV‐infected children who did not receive the programme. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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