Autonomic and enteric function profiling can predict disordered gastric emptying in diabetic gastropathy.
Gastric emptying tests (GET) are the gold standard for diagnosing gastroparesis, but many patients do not have delayed emptying. We aimed to examine the combination of autonomic nervous system testing (ANS) and the enteric measure (ENS) of electrogastrography (EGG) to predict disordered GET. Seventy...
| Publicado en: | Medical & Biological Engineering & Computing Vol. 59; no. 2; pp. 327 - 333 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Feb2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=148630192&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 148630192 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: Feb2021 vid: 59 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 148630192 148059811 148630192 NLM33433835 10.1007/s11517-020-02300-y NLM33433835 148630192 ppf: 327 ppct: 6 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Autonomic and enteric function profiling can predict disordered gastric emptying in diabetic gastropathy. aug: au: Hassan, Hamza Ganguli, Surosree Rashed, Hani Johnson, William Bhandari, Bikash Abell, Thomas affil: Department of Medicine, Division of GI, Hepatology and Nutrition, University of Louisville, 550 South Jackson Street, 40202, Louisville, Kentucky, USA sug: subj: Diabetes Mellitus Gastroparesis Diagnosis Diabetic Neuropathies Gastrointestinal Motility Autonomic Nervous System Adult Adult: 19-44 years ab: Gastric emptying tests (GET) are the gold standard for diagnosing gastroparesis, but many patients do not have delayed emptying. We aimed to examine the combination of autonomic nervous system testing (ANS) and the enteric measure (ENS) of electrogastrography (EGG) to predict disordered GET. Seventy-six patients (47 F, 29 M mean age 40 years) with diabetes mellitus underwent evaluation for end-organ failure including gastroparesis. ANS testing assessed autonomic function by finger capillary pulse to positional changes (PAR), vasoconstriction to cold (VC), and EKG R-R interval change (RRI) with deep breathing; the ENS measures of cutaneous EGG assessed gastric myoelectrical activity. Solid (S) GET subgroups were based on 50% emptying (TS50). Via linear regression analysis: VC, PAR, and EGG had a significant inverse correlation with GET TS50 and decreased in response to a delay in gastric emptying (p < 0.05). Via ordinal logistic regression RRI and EGG-predicted gastric emptying (p < 0.01). Patients with a higher RRI and EGG value were 0.93 and 0.14 times more likely to be diagnosed with rapid gastric emptying. The areas under the curve for receiver operator characteristics (AUROC) for all measures were 0.72 in comparison to 0.59 with EGG. Based on the results, four components (RRI, VC, PAR, and EGG) quantitatively describe gastric emptying in patients with signs of diabetic gastropathy better than EGG alone. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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