Short‐period temporal repolarization dispersion in subjects with atrial fibrillation and decompensated heart failure.
Background/objectives: The association between chronic heart failure (CHF) and permanent atrial fibrillation is very frequent. The repolarization duration was already found predictive for atrial fibrillation. Aim of this study was to evaluate the influence of atrial fibrillation on short period repo...
| Published in: | Pacing & Clinical Electrophysiology Vol. 44; no. 2; pp. 327 - 334 |
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| Main Authors: | , , , , , , , , , , |
| Format: | equations & formulas research tables/charts Journal Article |
| Published: |
Wiley-Blackwell
Feb2021
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=148723245&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 148723245 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01478389 4F8 jtl: Pacing & Clinical Electrophysiology issn: 01478389 maglogo: Y pubinfo: dt: Feb2021 vid: 44 iid: 2 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 148723245 148055637 148723245 148723245 10.1111/pace.14158 148723245 ppf: 327 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Short‐period temporal repolarization dispersion in subjects with atrial fibrillation and decompensated heart failure. aug: au: Piccirillo, Gianfranco Moscucci, Federica Bertani, Gaetano Lospinuso, Ilaria Sabatino, Teresa Zaccagnini, Giulia Crapanzano, Davide Diego, Ilaria Di Corrao, Andrea Rossi, Pietro Magrì, Damiano affil: Dipartimento di Scienze Cliniche, Internistiche, Anestesiologiche e Cardiovascolari, Policlinico Umberto I, "Sapienza", University of Rome, Rome, Italy sug: subj: Atrial Fibrillation Heart Failure Physiopathology Electrocardiography Methods Human Mortality Odds Ratio Confidence Intervals Natriuretic Peptide, Brain Descriptive Statistics ab: Background/objectives: The association between chronic heart failure (CHF) and permanent atrial fibrillation is very frequent. The repolarization duration was already found predictive for atrial fibrillation. Aim of this study was to evaluate the influence of atrial fibrillation on short period repolarization variables in decompensated CHF patients. Method: We used 5 min ECG recordings to assess the mean, standard deviation (SD), and normalized variance (NV) of the following variables: QT end (QTe), QT peak (QTp), and T peak to T end (Te) in 121 decompensated CHF, of whom 40 had permanent atrial fibrillation, too. We reported also the 30‐day mortality. Results: QTpSD (p <.01), TeSD (p <.01), QTpVN (p <.01), and TeVN (p <.01) were higher in the atrial fibrillation than among sinus rhythm CHF subjects. Multivariable logistic analysis selected only TeSD (odd ratio, o.r.: 1.32, 95% confidence interval, c.i.: 1.06–1.65, p:.015) associated with atrial fibrillation. A total of 27 patients died during the 30‐days follow‐up (overall mortality rate 22%), 7 (18%), and 20 (25%) respectively in the atrial fibrillation and sinus rhythm patients. Furthermore, the following variables were associated to the morality risk: NT‐pro Brain Natriuretic Peptide (o.r.: 1.00, 95% c.i.: 1.00–1.00, p:.041), left ventricular end diastolic diameter (o.r.: 0.81, 95% c.i.: 0.67–0.96, p:.010), and Te mean (o.r.: 1.04, 95% c.i.: 1.02–1.09, p:.012). Conclusion: In decompensated CHF subjects, Te mean seems be associated to mortality and TeSD to the permanent atrial fibrillation. We could hypothesize that, during severe CHF, the multi‐level ionic CHF channel derangement could be critical in influencing these non‐invasive markers. (ClinicalTrials.gov number, NCT04127162). pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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