Is replacing sedentary time with bouts of physical activity associated with inflammatory biomarkers in children?

This study aimed to investigate the theoretical impact of reallocating a specific amount of sedentary time with an equal amount of (a) total and (b) ≥1‐minute bout‐accumulated time spent in different activity intensities, on inflammatory biomarkers in 8‐ to 9‐year‐old children. Accelerometry and inf...

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Published in:Scandinavian Journal of Medicine & Science in Sports (John Wiley & Sons, Inc.) Vol. 31; no. 3; pp. 733 - 742
Main Authors: Verswijveren, Simone J. J. M., Salmon, Jo, Daly, Robin M., Della Gatta, Paul A., Arundell, Lauren, Dunstan, David W., Hesketh, Kylie D., Cerin, Ester, Ridgers, Nicola D.
Format: research tables/charts Journal Article
Published: John Wiley & Sons, Inc. Mar2021
Online Access:View this record in EBSCOhost
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      jtl: Scandinavian Journal of Medicine & Science in Sports (John Wiley & Sons, Inc.)
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      dt: Mar2021
      vid: 31
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      pub: John Wiley & Sons, Inc.
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        10.1111/sms.13879
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        atl: Is replacing sedentary time with bouts of physical activity associated with inflammatory biomarkers in children?
      aug:
        au:
          Verswijveren, Simone J. J. M.
          Salmon, Jo
          Daly, Robin M.
          Della Gatta, Paul A.
          Arundell, Lauren
          Dunstan, David W.
          Hesketh, Kylie D.
          Cerin, Ester
          Ridgers, Nicola D.
        affil: Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong VIC,, Australia
      sug:
        subj:
          Inflammation Risk Factors
          Biological Markers Blood
          Sedentary Behavior
          Physical Activity
          Human
          C-Reactive Protein Blood
          Interleukins Blood
          Descriptive Statistics
          Child
          Child: 6-12 years
      ab: This study aimed to investigate the theoretical impact of reallocating a specific amount of sedentary time with an equal amount of (a) total and (b) ≥1‐minute bout‐accumulated time spent in different activity intensities, on inflammatory biomarkers in 8‐ to 9‐year‐old children. Accelerometry and inflammatory biomarker baseline data from the Transform‐Us! Study (complete cases n = 149) were utilized. Isotemporal linear models with the Gaussian distribution and identity link functions were used to assess associations between the activity replacements and seven individual inflammatory biomarkers, including C‐reactive protein (CRP), and Interleukin (IL)‐2, IL‐6, IL‐8, and IL‐10, as well as combined inflammatory and pro‐inflammatory composite scores. Eighty‐five percent of children met physical activity recommendations. Replacing 10 minutes of sedentary time per day with VPA, regardless of how this was accumulated, was beneficially associated with CRP and both combined composite scores. In contrast, replacing 10 min/day of sedentary time with ≥ 1‐minute MPA bouts was detrimentally associated with CRP and the inflammatory composite score. Substitutions with other activity intensities were not significantly associated with any individual inflammatory biomarkers, or combined inflammatory and pro‐inflammatory composite scores. In healthy and active school‐aged children, evidence of the theoretical impact of replacing sedentary time with physical activity, regardless of intensity or accumulation, on markers of systemic inflammation was limited. Longitudinal research is needed to investigate the long‐term impacts of reallocating sedentary time with physical activity, and particularly VPA, for inflammatory biomarkers in children, including those with increased risk of inflammation.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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