MRF-RFS: A Modified Random Forest Recursive Feature Selection Algorithm for Nasopharyngeal Carcinoma Segmentation.

Background: An accurate and reproducible method to delineate tumor margins is of great importance in clinical diagnosis and treatment. In nasopharyngeal carcinoma (NPC), due to limitations such as high variability, low contrast, and discontinuous boundaries in presenting soft tissues, tumor margin c...

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Publicado en:Methods of Information in Medicine Vol. 59; no. 4/5; pp. 151 - 162
Autores principales: Fei, Yuchen, Zhang, Fengyu, Zu, Chen, Hong, Mei, Peng, Xingchen, Xiao, Jianghong, Wu, Xi, Zhou, Jiliu, Wang, Yan
Formato: Journal Article
Publicado: Thieme Medical Publishing Inc. 2020
Acceso en línea:Ver este registro en EBSCOhost
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      dt: 2020
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      pub: Thieme Medical Publishing Inc.
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        10.1055/s-0040-1721791
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        atl: MRF-RFS: A Modified Random Forest Recursive Feature Selection Algorithm for Nasopharyngeal Carcinoma Segmentation.
      aug:
        au:
          Fei, Yuchen
          Zhang, Fengyu
          Zu, Chen
          Hong, Mei
          Peng, Xingchen
          Xiao, Jianghong
          Wu, Xi
          Zhou, Jiliu
          Wang, Yan
        affil: School of Computer Science, Sichuan University, Chengdu, Sichuan, People's Republic of China
      sug:
        subj:
          Nasopharyngeal Neoplasms
          Algorithms
          Magnetic Resonance Imaging
          Reproducibility of Results
          Scales
      ab: Background: An accurate and reproducible method to delineate tumor margins is of great importance in clinical diagnosis and treatment. In nasopharyngeal carcinoma (NPC), due to limitations such as high variability, low contrast, and discontinuous boundaries in presenting soft tissues, tumor margin can be extremely difficult to identify in magnetic resonance imaging (MRI), increasing the challenge of NPC segmentation task.Objectives: The purpose of this work is to develop a semiautomatic algorithm for NPC image segmentation with minimal human intervention, while it is also capable of delineating tumor margins with high accuracy and reproducibility.Methods: In this paper, we propose a novel feature selection algorithm for the identification of the margin of NPC image, named as modified random forest recursive feature selection (MRF-RFS). Specifically, to obtain a more discriminative feature subset for segmentation, a modified recursive feature selection method is applied to the original handcrafted feature set. Moreover, we combine the proposed feature selection method with the classical random forest (RF) in the training stage to take full advantage of its intrinsic property (i.e., feature importance measure).Results: To evaluate the segmentation performance, we verify our method on the T1-weighted MRI images of 18 NPC patients. The experimental results demonstrate that the proposed MRF-RFS method outperforms the baseline methods and deep learning methods on the task of segmenting NPC images.Conclusion: The proposed method could be effective in NPC diagnosis and useful for guiding radiation therapy.
      pubtype: Academic Journal
      doctype: Journal Article
      ougenre: Article
    language: English
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