Magnetic resonance elastography to quantify liver disease severity in autosomal recessive polycystic kidney disease.
Objectives: To evaluate whether liver and spleen magnetic resonance elastography (MRE) can measure the severity of congenital hepatic fibrosis (CHF) and portal hypertension (pHTN) in individuals with autosomal recessive polycystic kidney disease (ARPKD), and to examine correlations between liver MRE...
| Publicado en: | Abdominal Radiology Vol. 46; no. 2; pp. 570 - 581 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Feb2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=148890935&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 148890935 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: Feb2021 vid: 46 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 148890935 144940135 10.1007/s00261-020-02694-1 148890935 ppf: 570 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Magnetic resonance elastography to quantify liver disease severity in autosomal recessive polycystic kidney disease. aug: au: Hartung, Erum A. Calle-Toro, Juan S. Lopera, Carolina Maya Wen, Jessica Carson, Robert H. Dutt, Mohini Howarth, Kathryn Furth, Susan L. Darge, Kassa Serai, Suraj D. affil: Division of Nephrology, Children's Hospital of Philadelphia, 3401 Civic Center Boulevard, 19104, Philadelphia, PA, USA sug: ab: Objectives: To evaluate whether liver and spleen magnetic resonance elastography (MRE) can measure the severity of congenital hepatic fibrosis (CHF) and portal hypertension (pHTN) in individuals with autosomal recessive polycystic kidney disease (ARPKD), and to examine correlations between liver MRE and ultrasound (US) elastography. Methods: Cross-sectional study of nine individuals with ARPKD and 14 healthy controls. MRE was performed to measure mean liver and spleen stiffness (kPa); US elastography was performed to measure point shear wave speed (SWS) in both liver lobes. We compared: (1) MRE liver and spleen stiffness between controls vs. ARPKD; and (2) MRE liver stiffness between participants with ARPKD without vs. with pHTN, and examined correlations between MRE liver stiffness, spleen length, platelet counts, and US elastography SWS. Receiver operating characteristic (ROC) analysis was performed to examine diagnostic accuracy of liver MRE. Results: Participants with ARPKD (median age 16.8 [IQR 13.3, 18.9] years) had higher median MRE liver stiffness than controls (median age 14.7 [IQR 9.7, 16.7 years) (2.55 vs. 1.92 kPa, p = 0.008), but MRE spleen stiffness did not differ. ARPKD participants with pHTN had higher median MRE liver stiffness than those without (3.60 kPa vs 2.49 kPa, p = 0.05). Liver MRE and US elastography measurements were strongly correlated. To distinguish ARPKD vs. control groups, liver MRE had 78% sensitivity and 93% specificity at a proposed cut-off of 2.48 kPa [ROC area 0.83 (95% CI 0.63–1.00)]. Conclusion: Liver MRE may be a useful quantitative method to measure the severity of CHF and pHTN in individuals with ARPKD. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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