Hyperbaric oxygen therapy for refractory pyoderma gangrenosum: a salvage treatment.
A 42-year-old woman with left-side ulcerative colitis (E2 – rectum to splenic flexure) was diagnosed with pyoderma gangrenosum (PG) on a persistent ulcerated wound with peripheral erythema, in the left leg’s gemelar surface, associated with tenderness and pain. Due to incomplete response to wound ca...
| Publicado en: | BMJ Case Reports Vol. 14; pp. 1 - 5 |
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| Autores principales: | , , , |
| Formato: | Journal Article |
| Publicado: |
BMJ Publishing Group
2/18/2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=148955368&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 148955368 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1757790X B755 jtl: BMJ Case Reports issn: 1757790X maglogo: N pubinfo: dt: 2/18/2021 vid: 14 pid: 8280 pub: BMJ Publishing Group artinfo: ui: 148955368 10.1136/bcr-2020-238638 148955368 ppf: 1 ppct: 4 formats: tig: atl: Hyperbaric oxygen therapy for refractory pyoderma gangrenosum: a salvage treatment. aug: au: Sousa Magalhães, Rui de João Moreira, Maria Rosa, Bruno Cotter, José affil: Gastroenterology Department, Hospital Senhora da Oliveira, Guimarães, Portugal. sug: ab: A 42-year-old woman with left-side ulcerative colitis (E2 – rectum to splenic flexure) was diagnosed with pyoderma gangrenosum (PG) on a persistent ulcerated wound with peripheral erythema, in the left leg’s gemelar surface, associated with tenderness and pain. Due to incomplete response to wound care and oral prednisolone, treatment with infliximab was initiated. As PG remained unresponsive after 12 weeks, the patient was switched to adalimumab with concomitant oral prednisolone. Before the second induction dosage of adalimumab, the refractory PG complicated with a superinfection by Pseudomonas aeruginosa. A course of wide spectrum antibiotic therapy, daily wound care including negative pressure bandages and a physiotherapy rehabilitation programme controlled the infection, but the pyoderma persisted non- healed, with visible deep muscle layers and tendons. We proposed hyperbaric oxygen therapy in addition to weekly adalimumab, achieving full remission of the PG and recovering of the left foot’s function. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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