| Summary: | Efficient strategies for testing large numbers of patients must be developed to limit the spread of coronavirus disease 2019 (COVID-19). We demonstrate that our drive-through model is an efficient method of testing large numbers of patients during a pandemic. In the drive-through, cost per patient and personal protective equipment use were significantly less than in 3 brick-and-mortar clinics providing testing. We provide an example of effective nurse practitioner leadership in a drive-through testing site and demonstrate that nurse practitioners are ideally suited to provide leadership given their adaptability, ability to function in a variety of settings, and extensive experience with care coordination and logistics. • Redeployed nurse practitioners can effectively provide clinical leadership in COVID-19 testing sites. • Drive-through COVID-19 testing allows for rapid testing of high volumes of patients. • Drive-through testing is cost-effective and generates positive clinical outcomes. • Drive-through testing uses substantially less personal protective equipment than traditional clinics. • Nurse practitioners are collaborative and adaptable, qualities essential to the COVID-19 response.
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