Dopaminergic modulation of reward discounting in healthy rats: a systematic review and meta-analysis.
Rationale: Although numerous studies have suggested that pharmacological alteration of the dopamine (DA) system modulates reward discounting, these studies have produced inconsistent findings. Objectives: Here, we conducted a systematic review and pre-registered meta-analysis to evaluate DA drug-med...
| Published in: | Psychopharmacology Vol. 238; no. 3; pp. 711 - 724 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Published: |
Springer Nature
Mar2021
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=149026264&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 149026264 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: Mar2021 vid: 238 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 149026264 147213834 10.1007/s00213-020-05723-5 149026264 ppf: 711 ppct: 13 formats: fmt: @attributes: type: P tig: atl: Dopaminergic modulation of reward discounting in healthy rats: a systematic review and meta-analysis. aug: au: Castrellon, Jaime J. Meade, James Greenwald, Lucy Hurst, Katlyn Samanez-Larkin, Gregory R. affil: Department of Psychology & Neuroscience, Duke University, Durham, NC, USA sug: ab: Rationale: Although numerous studies have suggested that pharmacological alteration of the dopamine (DA) system modulates reward discounting, these studies have produced inconsistent findings. Objectives: Here, we conducted a systematic review and pre-registered meta-analysis to evaluate DA drug-mediated effects on reward discounting of time, probability, and effort costs in studies of healthy rats. This produced a total of 1343 articles to screen for inclusion/exclusion. From the literature, we identified 117 effects from approximately 1549 individual rats. Methods: Using random effects with maximum-likelihood estimation, we meta-analyzed placebo-controlled drug effects for (1) DA D1-like receptor agonists and (2) antagonists, (3) D2-like agonists and (4) antagonists, and (5) DA transporter-modulating drugs. Results: Meta-analytic effects showed that DAT-modulating drugs decreased reward discounting. While D1-like and D2-like antagonists both increased discounting, agonist drugs for those receptors had no significant effect on discounting behavior. A number of these effects appear contingent on study design features like cost type, rat strain, and microinfusion location. Conclusions: These findings suggest a nuanced relationship between DA and discounting behavior and urge caution when drawing generalizations about the effects of pharmacologically manipulating dopamine on reward-based decision-making. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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