Attention deficit hyperactivity disorder medications and BMI trajectories: The role of medication type, sex and age.
Summary: Objectives: Attention deficit hyperactivity disorder (ADHD) and the medications used to treat it are associated with obesity. Stimulants lead to weight loss, while antipsychotics and antidepressants lead to weight gain. Little is known, however, how alpha‐2‐agonists impact weight, or the in...
| Publicado en: | Pediatric Obesity Vol. 16; no. 4; pp. 1 - 8 |
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| Autores principales: | , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Apr2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=149047817&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 149047817 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20476302 ETV7 jtl: Pediatric Obesity issn: 20476302 maglogo: Y pubinfo: dt: Apr2021 vid: 16 iid: 4 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 149047817 148578077 149047817 149047817 10.1111/ijpo.12738 149047817 ppf: 1 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Attention deficit hyperactivity disorder medications and BMI trajectories: The role of medication type, sex and age. aug: au: Gurka, Matthew J. Siddiqi, Siraj U. Filipp, Stephanie L. Mercado, Rebeccah Thompson, Lindsay A. Janicke, David M. Shenkman, Elizabeth A. affil: Department of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Gainesville Florida, USA sug: subj: Attention Deficit Hyperactivity Disorder Drug Therapy Adrenergic alpha-Agonists Therapeutic Use Adrenergic alpha-Agonists Pharmacodynamics Body Weight Drug Effects Body Mass Index Age Factors Sex Factors Human Descriptive Statistics Prospective Studies Electronic Health Records Child, Preschool Child Adolescence Young Adult Race Factors Ethnic Groups Antidepressive Agents Pharmacodynamics Antipsychotic Agents Pharmacodynamics Central Nervous System Stimulants Pharmacodynamics Child, Preschool: 2-5 years Child: 6-12 years Adolescent: 13-18 years ab: Summary: Objectives: Attention deficit hyperactivity disorder (ADHD) and the medications used to treat it are associated with obesity. Stimulants lead to weight loss, while antipsychotics and antidepressants lead to weight gain. Little is known, however, how alpha‐2‐agonists impact weight, or the independent effect on BMI of these four classes of medications, which are often prescribed concurrently. We aimed to estimate the proximal change in BMI associated with start of medication and to assess whether medication‐specific departures in BMI varied by age and sex. Study Design: We analysed longitudinal electronic health records from children (4‐19 years) with an ADHD diagnosis seen at one healthcare system (2011‐2018). Their BMI z‐scores were fit as a cubic function of age via a mixed model, separately by sex and adjusting for race/ethnicity. From this model, we estimated annual changes in BMI‐z after medication, allowing changes to vary by age and sex. Results: Among the 22 714 children with ADHD (mean initial age = 10.0), 4335 (19.1%) were never prescribed ADHD medication. The others (80.9%) experienced departures in BMI‐z after start of all four medication classes, which varied across age and sex (interaction P‐values <.01). All medications had larger impacts at younger ages. As expected, decreased BMI‐z was observed with stimulants, while antidepressants and antipsychotics led to BMI‐z increases; alpha‐agonists also were associated with BMI‐z increases. Conclusions: This longitudinal study revealed that ADHD medications are independently associated with proximal changes in BMI‐z after initiation, significantly varying by sex and age. Future research should study further the interactions of these medications on long‐term impacts on obesity. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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