The motivations, barriers, and sociodemographic characteristics of healthy Chinese volunteers in phase I research.
Purpose: To describe the motivations, barriers, and sociodemographic characteristics of healthy Chinese volunteers in phase I research and to demonstrate the factors influencing their willingness to participate in subsequent trials. Methods: Healthy subjects who participated in seven phase I trials...
| Publicado en: | European Journal of Clinical Pharmacology Vol. 77; no. 4; pp. 557 - 569 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Apr2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=149092721&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 149092721 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00316970 NP9 jtl: European Journal of Clinical Pharmacology issn: 00316970 maglogo: N pubinfo: dt: Apr2021 vid: 77 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 149092721 146965182 149092721 149092721 10.1007/s00228-020-03040-6 149092721 ppf: 557 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: The motivations, barriers, and sociodemographic characteristics of healthy Chinese volunteers in phase I research. aug: au: Wang, Zejuan Chen, Gang Liu, Xiaona Liu, Chen Song, Qingkun Wang, Jin affil: Department of Clinical Pharmacology, Aerospace Center Hospital, 15 Yuquan Road, Haidian District, 100049, Beijing, People's Republic of China sug: subj: Motivation Socioeconomic Factors Chinese Persons Research Subjects China Human Research Subject Recruitment Cross Sectional Studies Surveys Questionnaires Volunteer Workers Insurance, Health Insurance Coverage China ab: Purpose: To describe the motivations, barriers, and sociodemographic characteristics of healthy Chinese volunteers in phase I research and to demonstrate the factors influencing their willingness to participate in subsequent trials. Methods: Healthy subjects who participated in seven phase I trials at two centres were invited to participate in the cross-sectional survey at discharge by anonymously and voluntarily completing the self-administered questionnaire. Results: From 442 subjects asked to complete the questionnaire, a response rate of 94.8% (419) was obtained, and 72.8% of the respondents had participated in a mean of 2.0 ± 1.3 previous studies. Over 90% of the subjects indicated that the main motivations to participate trials were to help more people, to contribute to scientific research, and to obtain money. The top 5 barriers were time inconvenience, advertisement sources, potential risks associated with the drug, privacy, and the route of drug administration. Nearly half (49.6%) of the subjects were willing to participate in the next trial. The factors impacting the willingness of the subjects to participate in subsequent trials were gender, screening frequency, enrolment frequency, level of understanding of the research, two motivating factors (to make money and receive a free check-up), and ten barriers (e.g. risk, distance, living conditions, and trust). Conclusions: The majority of healthy Chinese subjects were young, were less well educated, had low income levels, and had poor medical insurance coverage. Given the multiple sources of motivation and complex barriers to trial participation, investigators and recruitment staff should consider ethics aspects to guarantee volunteer safety and well-being. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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