Serum levels of visfatin, sirtuin-1, and interleukin-6 in stable and acute exacerbation of chronic obstructive pulmonary disease.
Background: Visfatin is an adipokine that increased under inflammatory conditions. Moreover, sirtuin-1 possesses regulatory effects on inflammatory factors. In this study, we aimed to evaluate the serum level of visfatin in patients with stable and acute exacerbation of chronic obstructive pulmonary...
| Publicado en: | Journal of Research in Medical Sciences pp. 1 - 10 |
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| Autores principales: | , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wolters Kluwer India Pvt Ltd
Feb2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=149274033&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 149274033 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17351995 785C jtl: Journal of Research in Medical Sciences issn: 17351995 maglogo: N pubinfo: dt: Feb2021 pid: 16919 pub: Wolters Kluwer India Pvt Ltd artinfo: ui: 149274033 149274033 149274033 10.4103/jrms.JRMS_626_19 149274033 ppf: 1 ppct: 9 formats: tig: atl: Serum levels of visfatin, sirtuin-1, and interleukin-6 in stable and acute exacerbation of chronic obstructive pulmonary disease. aug: au: Ghobadi, Hassan Mokhtari, Sara Aslani, Mohammad Reza affil: Department of Internal Medicine, Division of Pulmonary, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran sug: subj: Transferases Blood Interleukins Blood Adipokines Blood Pulmonary Disease, Chronic Obstructive Blood Disease Exacerbation Human Case Control Studies Respiratory Function Tests Blood Specimen Collection Enzyme-Linked Immunosorbent Assay Descriptive Statistics Confidence Intervals Inflammation Mediators ab: Background: Visfatin is an adipokine that increased under inflammatory conditions. Moreover, sirtuin-1 possesses regulatory effects on inflammatory factors. In this study, we aimed to evaluate the serum level of visfatin in patients with stable and acute exacerbation of chronic obstructive pulmonary disease (AE-COPD). Materials and Methods: In a case--control study, thirty patients with stable COPD (S-COPD), thirty patients with AE-COPD, and thirty control subjects were enrolled. Pulmonary function tests and blood sampling were performed on all participants. Serum visfatin, sirtuin-1, and interleukin (IL)-6 levels were measured using the sandwich ELISA method and assessed their association with study parameters. Results: The findings of the current study revealed that serum levels of visfatin in AE-COPD patients were higher than those of healthy controls and S-COPD (for healthy control; standardized mean difference [SMD] = 2.63, 95% confidence interval [CI] =1.31--2.83, P < 0.001, and for S-COPD; SMD = 1.53, 95% CI = 0.21--2.85, P < 0.05). On the other hand, the serum levels of sirtuin-1 were higher in healthy controls compared to the S-COPD and AE-COPD patients (for S-COPD; SMD = 1.56, 95% CI = 0.018--3.11, P < 0.05, for AE-COPD; SMD = 1.50, 95% CI = 0.048--3.04, P < 0.05). Conclusion: Elevated visfatin and IL-6 levels demonstrated their pro-inflammatory effects in patients with COPD, especially in AE-COPD patients. In addition, the negative association found between serum visfatin and sirtuin-1 levels suggested the pathophysiologic and therapeutic roles of these factors in COPD patients. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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