Hypoglycemia in the emergency, is there any effect on endothelial and diastolic functions?
Introduction: Several homeostatic changes like an increase in sympathoadrenal response and oxidative stress occur in hypoglycemia. As a result of these findings, an increase in inflammation and preatherogenic factors is observed, and these changes may lead to endothelial dysfunction. Aim: Our study...
| Publicado en: | Echocardiography Vol. 38; no. 3; pp. 450 - 460 |
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| Autores principales: | , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Mar2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=149284947&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 149284947 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07422822 GSE jtl: Echocardiography issn: 07422822 maglogo: Y pubinfo: dt: Mar2021 vid: 38 iid: 3 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 149284947 148467049 149284947 149284947 10.1111/echo.14988 149284947 ppf: 450 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Hypoglycemia in the emergency, is there any effect on endothelial and diastolic functions? aug: au: Akhan, Onur Ardahanli, Isa affil: Cardiology, Bilecik Training and Research Hospital, Bilecik, Turkey sug: subj: Hypoglycemia Emergency Service Cardiovascular Risk Factors Endothelial Cells Physiology Human Cross Sectional Studies Case Control Studies Echocardiography Hematologic Tests Internal Medicine Age Factors Body Weight Body Height Body Mass Index Vitamin B12 ab: Introduction: Several homeostatic changes like an increase in sympathoadrenal response and oxidative stress occur in hypoglycemia. As a result of these findings, an increase in inflammation and preatherogenic factors is observed, and these changes may lead to endothelial dysfunction. Aim: Our study aims to reveal possible cardiac risks (systolic‐diastolic functions and endothelial dysfunctions) in patients who have applied to the emergency department with hypoglycemia. Methods: This cross‐sectional, case–control study included 46 hypoglycemia patients who admitted to the emergency with symptoms compatible with hypoglycemia and diagnosed with hypoglycemia and 30 healthy volunteers. All patients were evaluated with baseline echocardiography, tissue‐Doppler imaging (carotid and brachial artery). Also, the fasting blood tests of the patients referred to the internal medicine department were examined. Results: There were no differences between the groups regarding age, weight, body mass index, and systolic blood pressure. Total cholesterol, LDL, HDL, Vitamin B12, TSH, and fasting blood glucose levels were similar in the groups' blood tests (all P values >.05). We observed a statistically significant decrease in diastolic dysfunction parameters: E/A and E/e' ratios (respectively, P =.020 and 0.026). It was shown that insulin resistance was influential in forming these considerable differences. The patient group observed that the carotid intima–media thickness was more remarkable (P =.001), and the brachial flow‐mediated dilatation value was smaller (P =.003), giving an idea about endothelial functions. Conclusion: As a message, we can say that hypoglycemia may affect diastolic functions in addition to endothelial dysfunction. Therefore, even young individuals without any chronic diseases may need follow‐up in terms of possible risks. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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