Growth patterns and their contributing factors among HIV‐exposed uninfected infants.
With expanded HIV treatment and prevention programmes, most infants born to HIV‐positive women are uninfected, but the patterns and determinants of their growth are not well described. This study aimed to assess growth patterns in a cohort of HIV‐exposed uninfected (HEU) infants who participated in...
| Publicado en: | Maternal & Child Nutrition Vol. 17; no. 2; pp. 1 - 11 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Apr2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=149452396&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 149452396 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17408695 0LU jtl: Maternal & Child Nutrition issn: 17408695 maglogo: Y pubinfo: dt: Apr2021 vid: 17 iid: 2 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 149452396 148575313 149452396 149452396 10.1111/mcn.13110 149452396 ppf: 1 ppct: 10 formats: tig: atl: Growth patterns and their contributing factors among HIV‐exposed uninfected infants. aug: au: Ndiaye, Aminata Suneson, Klara Njuguna, Irene Ambler, Gwen Hanke, Tomas John‐Stewart, Grace Jaoko, Walter Reilly, Marie affil: Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden sug: subj: Infant Development HIV Infections Mothers HIV-Positive Persons Disease Transmission, Vertical Human AIDS Vaccines Anti-Retroviral Agents Anthropometry Linear Regression Body Height Fetal Weight ab: With expanded HIV treatment and prevention programmes, most infants born to HIV‐positive women are uninfected, but the patterns and determinants of their growth are not well described. This study aimed to assess growth patterns in a cohort of HIV‐exposed uninfected (HEU) infants who participated in an experimental HIV vaccine trial and to test for associations with maternal and infant factors, including in‐utero exposure to antiretroviral therapy (ART), mode of delivery, exclusive breastfeeding, mother's education and receipt of the vaccine. Infants in the trial were seen at regular clinic visits from birth to 48 weeks of age. From the anthropometric measurements at these visits, weight‐for‐age z‐scores (WAZ), weight‐for‐length z‐scores (WLZ) and length‐for‐age z‐scores (LAZ) were computed using World Health Organization (WHO) software and reference tables. Growth patterns were investigated with respect to maternal and infant factors, using linear mixed regression models. From 94 infants included at birth, growth data were available for 75.5% at 48 weeks. The determinants of infant growth in this population are multifactorial: infant LAZ during the first year was significantly lower among infants delivered by caesarean section (p = 0.043); both WAZ and LAZ were depressed among infants with longer exposure to maternal ART (WAZ: p = 0.015; LAZ: p < 0.0001) and among infants of mothers with lower educational level (WAZ: p = 0.038; LAZ: p < 0.0001); the effect of maternal education was modified by breastfeeding practice, with no differences seen in exclusively breastfed infants. These findings inform intervention strategies to preserve growth in this vulnerable infant population. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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