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CCR5Δ32 Deletion as a Protective Factor in Czech First-Wave COVID-19 Subjects.

Infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease (COVID-19), has spread widely around the globe. Significant inter-individual differences have been observed during the course of the infection, which suggests that genetic susceptibil...

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Published in:Physiological Research Vol. 70; no. 1; pp. 111 - 115
Main Authors: HUBACEK, Jaroslav A., DUSEK, Ladislav, MAJEK, Ondrej, ADAMEK, Vaclav, CERVINKOVA, Tereza, DLOUHA, Dana, PAVEL, Jozef, ADAMKOVA, Vera
Format: Journal Article
Published: Institute of Physiology, Academy of Sciences of the Czech Republic Feb2021
Online Access:View this record in EBSCOhost
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      dt: Feb2021
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      pub: Institute of Physiology, Academy of Sciences of the Czech Republic
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        10.33549/physiolres.934647
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        atl: CCR5Δ32 Deletion as a Protective Factor in Czech First-Wave COVID-19 Subjects.
      aug:
        au:
          HUBACEK, Jaroslav A.
          DUSEK, Ladislav
          MAJEK, Ondrej
          ADAMEK, Vaclav
          CERVINKOVA, Tereza
          DLOUHA, Dana
          PAVEL, Jozef
          ADAMKOVA, Vera
        affil: Experimental Medicine Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
      sug:
      ab: Infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease (COVID-19), has spread widely around the globe. Significant inter-individual differences have been observed during the course of the infection, which suggests that genetic susceptibility may be a contributing factor. CC chemokine receptor 5 (CCR5), which acts as a co-receptor for the entry of HIV-1 into cells, is promising candidate whose can have an influence on SARS-CoV-2 infection. A genetic mutation known as CCR5 Δ32, consisting of a 32-nucleotide deletion, encodes a truncated protein that protects homozygous carriers of the deletion from HIV-1 infection. Similarly, inhibition of CCR5 seems to be protective against COVID-19. In our study, we successfully genotyped 416 first-wave SARS-CoV-2-positive infection survivors (164 asymptomatic and 252 symptomatic) for CCR5 Δ32, comparing them with a population based sample of 2,404 subjects. We found the highest number (P=0.03) of CCR5 Δ32 carriers in SARS-CoV-2-positive/COVID-19-asymptomatic subjects (23.8 %) and the lowest number in SARS-CoV-2-positive/COVID-19-symptomatic patients (16.7 %), with frequency in the control population in the middle (21.0 %). We conclude that the CCR5 Δ32 I/D polymorphism may have the potential to predict the severity of SARS-CoV-2 infection.
      pubtype: Academic Journal
      doctype: Journal Article
      ougenre: Article
    language: English
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