Evaluation of iron overload by cardiac and liver T2* in β-thalassemia: Correlation with serum ferritin, heart function and liver enzymes.
Introduction: In this study, we aimed to assess the relationship of cardiac and hepatic T2* magnetic resonance imaging (MRI) values as a gold standard for detecting iron overload with serum ferritin level, heart function, and liver enzymes as alternative diagnostic methods. Methods: A total 58 patie...
| Publicado en: | Journal of Cardiovascular & Thoracic Research Vol. 13; no. 1; pp. 54 - 61 |
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| Autores principales: | , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Tabriz University of Medical Sciences
2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=149525766&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 149525766 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20085117 BL7R jtl: Journal of Cardiovascular & Thoracic Research issn: 20085117 maglogo: N pubinfo: dt: 2021 vid: 13 iid: 1 pid: 69573 pub: Tabriz University of Medical Sciences artinfo: ui: 149525766 149525766 149525766 10.34172/jcvtr.2021.18 149525766 ppf: 54 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Evaluation of iron overload by cardiac and liver T2* in β-thalassemia: Correlation with serum ferritin, heart function and liver enzymes. aug: au: Khadivi Heris, Hengameh Nejati, Babak Rezazadeh, Khatereh Sate, Hossein Dolatkhah, Roya Ghoreishi, Zohreh Esfahani, Ali affil: Department of Internal Medicine, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran sug: subj: Magnetic Resonance Imaging Iron Overload beta-Thalassemia Ferritin Blood Heart Physiology Liver Metabolism Enzymes Analysis Human Heart Radiography Liver Radiography Echocardiography Aspartate Aminotransferase Analysis Alanine Aminotransferase Analysis ab: Introduction: In this study, we aimed to assess the relationship of cardiac and hepatic T2* magnetic resonance imaging (MRI) values as a gold standard for detecting iron overload with serum ferritin level, heart function, and liver enzymes as alternative diagnostic methods. Methods: A total 58 patients with beta-thalassemia major who were all transfusion dependent were evaluated for the study. T2* MRI of heart and liver, echocardiography, serum ferritin level, and liver enzymes measurement were performed. The relationship between T2* MRI findings and other assessments were examined. Cardiac and hepatic T2* findings were categorized as normal, mild, moderate, and severe iron overload. Results: 22% and 11% of the patients were suffering from severe iron overload in heart and liver, respectively. The echocardiographic findings were not significantly different among different iron load categories in heart or liver. ALT level was significantly higher in patient with severe iron overload than those with normal iron load in heart (P =0.005). Also, AST level was significantly lower in normal iron load group than mild, moderate, and severe iron load groups in liver (P <0.05). The serum ferritin level was significantly inversely correlated with cardiac T2* values (r = -0.34, P =0.035) and hepatic T2* values (r = -0.52, P =0.001). Conclusion: Cardiac and hepatic T2* MRI indicated significant correlation with serum ferritin level. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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