3D Pharmacophore-Based Discovery of Novel K V 10.1 Inhibitors with Antiproliferative Activity.

Simple Summary: A novel structural class of inhibitors of the voltage-gated potassium channel KV10.1 was discovered by a ligand-based drug design method using a 3D pharmacophore model. The virtual screening hit compound ZVS-08 inhibited the channel in a voltage-dependent manner consistent with the a...

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Publicado en:	Cancers Vol. 13; no. 6; pp. 1244 - 1245
Autores principales:	Toplak, Žan, Hendrickx, Louise Antonia, Gubič, Špela, Možina, Štefan, Žegura, Bojana, Štern, Alja, Novak, Matjaž, Shi, Xiaoyi, Peigneur, Steve, Tytgat, Jan, Tomašič, Tihomir, Pardo, Luis A., Mašič, Lucija Peterlin, Roszik, Jason
Formato:	pictorial research tables/charts Journal Article
Publicado:	MDPI Mar2021
Acceso en línea:	Ver este registro en EBSCOhost