The Effects of Tau, Amyloid, and White Matter Lesions on Mobility, Dual Tasking, and Balance in Older People.
Background: This study aimed to investigate whether white matter lesions (WML), β-amyloid-, and tau pathologies are independently associated with mobility, dual tasking, and dynamic balance performance in older nondemented individuals.Methods: We included 299 older people (mean, SD, age: 71.8, 5.6 y...
| Publicado en: | Journals of Gerontology Series A: Biological Sciences & Medical Sciences Vol. 76; no. 4; pp. 683 - 692 |
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| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Oxford University Press / USA
Apr2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=149634654&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 149634654 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10795006 JGA jtl: Journals of Gerontology Series A: Biological Sciences & Medical Sciences issn: 10795006 maglogo: N pubinfo: dt: Apr2021 vid: 76 iid: 4 pid: 622 pub: Oxford University Press / USA artinfo: ui: 149634654 149634654 NLM32506119 149634654 10.1093/gerona/glaa143 NLM32506119 149634654 ppf: 683 ppct: 9 formats: tig: atl: The Effects of Tau, Amyloid, and White Matter Lesions on Mobility, Dual Tasking, and Balance in Older People. aug: au: Nilsson, Maria H Tangen, Gro Gujord Palmqvist, Sebastian Westen, Danielle van Mattsson-Carlgren, Niklas Stomrud, Erik Hansson, Oskar van Westen, Danielle affil: Department of Health Sciences, Faculty of Medicine, Lund University , Sweden sug: subj: Peptides Cerebrospinal Fluid Task Performance and Analysis Brain Nerve Tissue Proteins Cerebrospinal Fluid Symptoms Brain Pathology Balance, Postural Sweden Male Magnetic Resonance Imaging Methods Human Cognition Magnetic Resonance Imaging Statistics and Numerical Data Comorbidity Aged Geriatric Assessment Methods Female Comparative Studies Multicenter Studies Evaluation Research Validation Studies Aged: 65+ years Male Female ab: Background: This study aimed to investigate whether white matter lesions (WML), β-amyloid-, and tau pathologies are independently associated with mobility, dual tasking, and dynamic balance performance in older nondemented individuals.Methods: We included 299 older people (mean, SD, age: 71.8, 5.6 years) from the Swedish BioFINDER study, whereof 175 were cognitively unimpaired and 124 had mild cognitive impairment (MCI). In multivariable regression analyses, dependent variables included mobility (Timed Up & Go [TUG]), dual tasking (TUG with a simultaneous subtraction task, that is, TUG-Cog, as well as dual task cost), and balance (Figure-of-eight). The analyses were controlled for age, sex, education, diagnosis (ie, MCI), and comorbidity (stroke, diabetes, and ischemic heart disease). Independent variables included WML volume, and measures of β-amyloid (abnormal cerebrospinal fluid [CSF] Aβ42/40 ratio) and tau pathology (CSF phosphorylated tau [p-tau]).Results: Multivariable regression analyses showed that an increased WML volume was independently associated with decreased mobility, that is, TUG (standardized β = 0.247; p < .001). Tau pathology was independently associated with dual tasking both when using the raw data of TUG-Cog (β = 0.224; p = .003) and the dual-task cost (β= -0.246; p = .001). Amyloid pathology was associated with decreased balance, that is, Figure-of-eight (β = 0.172; p = .028). The independent effects of WML and tau pathology were mainly observed in those with MCI, which was not the case for the effects of amyloid pathology on balance.Conclusions: Common brain pathologies have different effects where WML are independently associated with mobility, tau pathology has the strongest effect on dual tasking, and amyloid pathology seems to be independently associated with balance. Although these novel findings need to be confirmed in longitudinal studies, they suggest that different brain pathologies have different effects on mobility, balance, and dual-tasking in older nondemented individuals. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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