A network meta-analysis protocol of efficacy and safety evaluation of different surgery regimens for varicocele patients with infertility: A study protocol.

Background: Surgical treatment of varicocele is still one of the most common important treatments for male infertility. Surgery regimens for varicocele (VC) is various, including high ligation, sub-inguinal, inguinal, retroperitoneal, laparoscopic, and microsurgery. The surgery regimens applied for...

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Publicado en:Medicine Vol. 100; no. 9; pp. 1 - 4
Autores principales: Xiao-dong Zhao, Xiao-ling Ma, Peng-cheng Ma, Jian-wen Wang, Zhao, Xiao-Dong, Ma, Xiao-Ling, Ma, Peng-Cheng, Wang, Jian-Wen
Formato: protocol Journal Article
Publicado: Lippincott Williams & Wilkins 3/5/2021
Acceso en línea:Ver este registro en EBSCOhost
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      dt: 3/5/2021
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      pub: Lippincott Williams & Wilkins
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        10.1097/MD.0000000000021150
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        atl: A network meta-analysis protocol of efficacy and safety evaluation of different surgery regimens for varicocele patients with infertility: A study protocol.
      aug:
        au:
          Xiao-dong Zhao
          Xiao-ling Ma
          Peng-cheng Ma
          Jian-wen Wang
          Zhao, Xiao-Dong
          Ma, Xiao-Ling
          Ma, Peng-Cheng
          Wang, Jian-Wen
        affil: Department of Reproductive Medicine, The First Hospital of Lanzhou University, Lanzhou, China.
      sug:
        subj:
          Infertility Surgery
          Surgery, Urologic, Male Methods
          Varicocele Surgery
          Systematic Review
          Meta Analysis
      ab: Background: Surgical treatment of varicocele is still one of the most common important treatments for male infertility. Surgery regimens for varicocele (VC) is various, including high ligation, sub-inguinal, inguinal, retroperitoneal, laparoscopic, and microsurgery. The surgery regimens applied for VC patients are various in clinic, however, the significance, advantages, and disadvantages of different varicocelectomies for male infertility are still in controversial. Therefore, this network meta-analysis is mainly to assess the relative efficacy and safety of different surgery regimens for VC patients with infertility.Methods: To compare the relative efficacy and safety among different varicocelectomies for VC patients, we systematic searched randomized controlled trials (RCTs) and non-RCTs were in five electronic databases: Pubmed, Web of Science, EMBASE database, Clinical Trials, and Cochrane Library. Using R-3.4.1 software to process and analyze data. The bias risk of RCTs and non-RCTs will be evaluated through the tool of Cochrane Handbook version 5.1.0 and non-randomized studies of interventions (ROBINS-I), respectively.Results and Conclusion: The result of this network meta-analysis aim is to evaluate the relative effectiveness and safety and rank the interventions among all surgery methods for VC patients and provide more evidence-based guidance in clinical practice.Protocol Registration Number: CRD42020162051.
      pubtype: Academic Journal
      doctype:
        protocol
        Journal Article
      ougenre: Article
    language: English
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