Anti-Inflammatory and Antimicrobial Activities of Compounds Isolated from Distichochlamys benenica.
Distichochlamys benenica is a native black ginger that grows in Vietnam. In point of fact, there is limitation of available information in the literature making mention of the chemical constituents and bioactive properties of this plant. This study is aimed at isolating trans-o-coumaric acid (1), tr...
| Publicado en: | BioMed Research International pp. 1 - 11 |
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| Autores principales: | , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
4/7/2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=149688342&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 149688342 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 4/7/2021 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 149688342 149688342 149688342 10.1155/2021/6624347 149688342 ppf: 1 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Anti-Inflammatory and Antimicrobial Activities of Compounds Isolated from Distichochlamys benenica. aug: au: Pham, Ty Viet Hoang, Hanh Nhu Thi Nguyen, Hoai Thi Nguyen, Hien Minh Huynh, Cong Thang Vu, Thien Y Do, Anh Thu Nguyen, Nguyen Hoai Do, Bich Hang affil: Faculty of Chemistry, University of Education, Hue University, 34 Le Loi, Hue City, Vietnam sug: subj: Plants, Medicinal Therapeutic Use Plants, Medicinal Pharmacodynamics Edema Therapy Animal Studies Molecular Structure Acids, Carbocyclic Analysis Edema Prevention and Control Cox-2 Inhibitors Antiinflammatory Agents Antiinfective Agents Gram-Positive Bacteria ab: Distichochlamys benenica is a native black ginger that grows in Vietnam. In point of fact, there is limitation of available information in the literature making mention of the chemical constituents and bioactive properties of this plant. This study is aimed at isolating trans-o-coumaric acid (1), trans-cinnamic acid (2), and borneol (3) from the rhizomes of D. benenica Q.B.Nguyen & Škorničk and evaluate the anti-inflammatory and antimicrobial activities of 1-3 using the carrageenan paw edema model and the dilution broth method, respectively. This revealed that 1 was as effective as diclofenac in reducing the intensity of the edema development. The in silico research showed that the activity of 1 might be derived from inhibiting COX-2 by generating h-bonds at the positions of Arg 120, Tyr 355, and Arg 513 residues. The antimicrobial activities against Gram-positive strains (Staphylococcus aureus and Bacillus subtilis) were comparable, with the minimum inhibitory concentrations ranging from 1.52 to 3.37 mM. This is the first study of the bioactivity of compounds isolated from D. benenica Q.B.Nguyen & Škorničk. Our results suggest that 1 may be a nature-derived compound which demonstrates the anti-inflammatory properties and inhibit the proliferation of several Gram-positive bacteria. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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