Altered resting cerebral blood flow specific to patients with diabetic retinopathy revealed by arterial spin labeling perfusion magnetic resonance imaging.
Background: Previous neuroimaging studies have shown that patients with diabetic retinopathy (DR) were accompanied by abnormalities in cerebral functional and structural architecture, whereas the resting cerebral blood flow (CBF) alterations in patients with DR are not well understood.Purpose: To ex...
| Publicado en: | Acta Radiologica Vol. 62; no. 4; pp. 524 - 533 |
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| Autores principales: | , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
Apr2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=149706403&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 149706403 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02841851 1XG jtl: Acta Radiologica issn: 02841851 maglogo: Y pubinfo: dt: Apr2021 vid: 62 iid: 4 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 149706403 146275451 149706403 NLM32551803 149706403 10.1177/0284185120932391 NLM32551803 149706403 ppf: 524 ppct: 9 formats: tig: atl: Altered resting cerebral blood flow specific to patients with diabetic retinopathy revealed by arterial spin labeling perfusion magnetic resonance imaging. aug: au: Huang, Xin Wen, Zhi Tong, Yan Qi, Chen-Xing Shen, Yin affil: Eye Center, Renmin Hospital of Wuhan University, Wuhan, Hubei, PR China sug: subj: Free Radicals Perfusion Magnetic Resonance Imaging Cerebrovascular Circulation Diabetic Retinopathy Physiopathology Diabetic Retinopathy Male Middle Age Adult Female Clinical Assessment Tools Human Middle Aged: 45-64 years Adult: 19-44 years Male Female ab: Background: Previous neuroimaging studies have shown that patients with diabetic retinopathy (DR) were accompanied by abnormalities in cerebral functional and structural architecture, whereas the resting cerebral blood flow (CBF) alterations in patients with DR are not well understood.Purpose: To explore CBF alterations in patients with DR using pseudo-continuous arterial spin labeling (pCASL) imaging.Material and Methods: Thirty-one individuals with DR (15 men, 16 women; mean age = 53.38 ± 9.12 years) and 33 healthy controls (HC) (12 men, 21 women; mean age = 51.61 ± 9.84 years) closely matched for age, sex, and education, underwent pCASL imaging scans. Two-sample T test was conducted to compare different CBF values between two groups.Results: Patients with DR exhibited significantly increased CBF values in the left middle temporal gyrus (Brodmann's area, BA 22) and the bilateral supplementary motor area (BA3) and decreased CBF values in the bilateral calcarine (BA17,18) and bilateral caudate relative to HC group (two-tailed, voxel level at P < 0.01, Gaussian random field (GRF), cluster level at P < 0.05). Moreover, the HbA1c (%) level showed a positive correlation with CBF values in the bilateral caudate (r = 0.473, P = 0.007) in patients with DR.Conclusion: Our results highlighted that patients with DR had abnormal CBF values in the visual cortices, caudate, middle temporal gyrus, and supplementary motor area, which might reflect vision and sensorimotor and cognition dysfunction in patients with DR. These findings might help us to understanding the neural mechanism of patients with DR. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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