Altered white matter structural networks in drug-naïve patients with obsessive-compulsive disorder.
White matter (WM) alteration is considered to be a vital neurological mechanism of obsessive-compulsive disorder (OCD). However, little is known regarding the changes in topological organization of WM structural network in OCD. We acquired diffusion tensor imaging (DTI) datasets from 28 drug-naïve O...
| Publicado en: | Brain Imaging & Behavior Vol. 15; no. 2; pp. 700 - 711 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Apr2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=149713761&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 149713761 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Apr2021 vid: 15 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 149713761 143951390 149713761 NLM32314200 10.1007/s11682-020-00278-7 NLM32314200 149713761 ppf: 700 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Altered white matter structural networks in drug-naïve patients with obsessive-compulsive disorder. aug: au: Zhou, Cong Ping, Liangliang Chen, Wei He, Mengxin Xu, Jian Shen, Zonglin Lu, Yi Shang, Binli Xu, Xiufeng Cheng, Yuqi affil: Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, 650032, Kunming, China sug: subj: Obsessive-Compulsive Disorder Brain Drugs Magnetic Resonance Imaging Scales ab: White matter (WM) alteration is considered to be a vital neurological mechanism of obsessive-compulsive disorder (OCD). However, little is known regarding the changes in topological organization of WM structural network in OCD. We acquired diffusion tensor imaging (DTI) datasets from 28 drug-naïve OCD patients and 28 well-matched healthy controls (HC). A deterministic fiber tracking approach was used to construct the whole-brain structural connectome. Group differences in global and nodal topological properties as well as rich-club organizations were compared by using graph theory analysis. The relationship between the altered network metrics and the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) was calculated. Compared with controls, OCD patients exhibited a significantly decreased small-worldness (σ), normalized clustering coefficient (γ) and shortest path length (Lp), as well as an increased global efficiency (Eglob). The nodal efficiency (Enodal) was found to be reduced in the left middle frontal gyrus, and increased in the right parahippocampal gyrus and bilateral putamen in OCD patients. Besides, OCD patients showed increased rich-club, feeder and local connection strength, and the connection strength of the rich-club was positively correlated with the total Y-BOCS score. Our findings emphasized a central role for the complicatedly changed topological architecture of brain structural networks in the pathological mechanism underlying OCD. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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