Non-aspirin NSAID use and mortality of endometrial cancer. A nationwide cohort study.
Purpose: Laboratory studies have shown anti-neoplastic properties of non-aspirin NSAID; however, no studies have examined the influence of non-aspirin NSAIDs as potential adjuvant cancer therapy in women with endometrial cancer. We therefore examined the association between post-diagnostic use of no...
| Publicado en: | Cancer Causes & Control Vol. 32; no. 5; pp. 515 - 524 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
May2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=149762257&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 149762257 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09575243 ODX jtl: Cancer Causes & Control issn: 09575243 maglogo: N pubinfo: dt: May2021 vid: 32 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 149762257 148876150 149762257 NLM33620641 10.1007/s10552-021-01402-8 NLM33620641 149762257 ppf: 515 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Non-aspirin NSAID use and mortality of endometrial cancer. A nationwide cohort study. aug: au: Sperling, Cecilie Dyg Verdoodt, Freija Aalborg, Gitte Lerche Dehlendorff, Christian Friis, Søren Kjaer, Susanne K. affil: Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark sug: subj: Endometrial Neoplasms Mortality Antiinflammatory Agents, Non-Steroidal Therapeutic Use Female Middle Age Aged, 80 and Over Aged Data Collection Cox Proportional Hazards Model Adult Prospective Studies Checklists Middle Aged: 45-64 years Aged, 80 & over Aged: 65+ years Adult: 19-44 years Female ab: Purpose: Laboratory studies have shown anti-neoplastic properties of non-aspirin NSAID; however, no studies have examined the influence of non-aspirin NSAIDs as potential adjuvant cancer therapy in women with endometrial cancer. We therefore examined the association between post-diagnostic use of non-aspirin NSAIDs and endometrial cancer mortality in Denmark.Methods: We identified all women with a primary endometrial cancer diagnosis between 2000 and 2012, who were alive one year after the diagnosis. Information on drug use, cause-specific mortality and potential confounders was obtained from nationwide health- and demographic registries. Cox regression models were used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between post-diagnostic non-aspirin NSAID use and endometrial cancer mortality.Results: Among 6 694 endometrial cancer patients with a maximum follow-up of 13 years, 753 women died from endometrial cancer. Post-diagnostic non-aspirin NSAID use (≥ 1 filled prescription) was associated with an overall HR of 1.15 (95% CI; 0.97-1.36) for endometrial cancer mortality, with higher HRs for the highest intensity of use (HR; 1.40, 95% CI; 1.11-1.77) and largest cumulative amount (HR; 1.56, 95% CI; 1.14-2.14).Conclusion: Our findings yielded no evidence that use of non-aspirin NSAIDs was associated with reduced endometrial cancer. Rather, we observed that high-intensity and large cumulative amount of non-aspirin NSAID use may be associated with increased endometrial cancer mortality. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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