Intestinal function is impaired in patients with Chronic Obstructive Pulmonary Disease.
Gastrointestinal symptoms are prevalent extrapulmonary systemic manifestations of Chronic Obstructive Pulmonary Disease (COPD), but have been rarely studied. We dissected the perturbations in intestinal function in human patients with COPD using comprehensive metabolic and physiological approaches....
| Publicado en: | Clinical Nutrition Vol. 40; no. 4; pp. 2270 - 2278 |
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| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
Apr2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=149781231&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 149781231 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02615614 8IC jtl: Clinical Nutrition issn: 02615614 maglogo: N pubinfo: dt: Apr2021 vid: 40 iid: 4 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 149781231 149781231 149781231 10.1016/j.clnu.2020.10.010 149781231 ppf: 2270 ppct: 8 formats: tig: atl: Intestinal function is impaired in patients with Chronic Obstructive Pulmonary Disease. aug: au: Kirschner, Sarah K. Deutz, Nicolaas E.P. Jonker, Renate Olde Damink, Steven W.M. Harrykissoon, Rajesh I. Zachria, Anthony J. Dasarathy, Srinivasan Engelen, Mariëlle P.K.J. affil: Center for Translational Research in Aging & Longevity, Department of Health & Kinesiology, Texas A&M University, College Station, TX, USA sug: subj: Pulmonary Disease, Chronic Obstructive Intestines Physiopathology Gut Microbiota Metabolism Human Nonexperimental Studies Confidence Intervals Descriptive Statistics ab: Gastrointestinal symptoms are prevalent extrapulmonary systemic manifestations of Chronic Obstructive Pulmonary Disease (COPD), but have been rarely studied. We dissected the perturbations in intestinal function in human patients with COPD using comprehensive metabolic and physiological approaches. In this observational study, small intestinal membrane integrity and active carrier-mediated glucose transport were quantified by sugar permeability test in 21 clinically stable patients with moderate to severe COPD (mean FEV 1 , 41.2 (3.2) % of predicted) and 16 healthy control subjects. Protein digestion and absorption was analyzed using stable tracer kinetic methods. Plasma acetate, propionate, and butyrate concentrations were measured as markers of intestinal microbial metabolism. Compared with healthy controls, non carrier-mediated permeability was higher (0.062 (95% CI [0.046, 0.078]) vs. 0.037 (95% CI [0.029, 0.045]), P = 0.009) and active glucose transport lower in COPD (31.4 (95% CI [23.4, 39.4])% vs. 48.0 (95% CI [37.8, 58.3])%, P = 0.010). Protein digestion and absorption was lower in COPD (0.647 (95% CI [0.588, 0.705]) vs. 0.823 (95% CI [0.737, 0.909]), P = 0007), and impairment greater in patients with dyspnea (P = 0.038), exacerbations in preceding year (P = 0.052), and reduced transcutaneous oxygen saturation (P = 0.051), and was associated with reduced physical activity score (P = 0.016) and lower quality of life (P = 0.0007). Plasma acetate concentration was reduced in COPD (41.54 (95% CI [35.17, 47.91]) vs. 80.44 (95% CI [54.59, 106.30]) μmol/L, P = 0.001) suggesting perturbed intestinal microbial metabolism. We conclude that intestinal dysfunction is present in COPD, worsens with increasing disease severity, and is associated with reduced quality of life. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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