MRI findings in children with congenital cytomegalovirus infection retrospectively diagnosed with dried umbilical cord.
Purpose: Brain MRI provides important information about suspected congenital CMV infection in neonatally underdiagnosed children. This study aimed to describe MRI findings in children in whom congenital CMV infection was not suspected during the neonatal period and was proven retrospectively. Method...
| Published in: | Neuroradiology Vol. 63; no. 5; pp. 761 - 769 |
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| Main Authors: | , , , , , , , , , |
| Format: | diagnostic images research tables/charts Journal Article |
| Published: |
Springer Nature
May2021
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=149789429&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 149789429 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: May2021 vid: 63 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 149789429 147212489 149789429 149789429 10.1007/s00234-020-02603-9 149789429 ppf: 761 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: MRI findings in children with congenital cytomegalovirus infection retrospectively diagnosed with dried umbilical cord. aug: au: Kidokoro, Hiroyuki Shiraki, Anna Torii, Yuka Tanaka, Masaharu Yamamoto, Hiroyuki Kurahashi, Hirokazu Maruyama, Koichi Okumura, Akihisa Natsume, Jun Ito, Yoshinori affil: Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8560, Nagoya, Aichi, Japan sug: subj: Cytomegalovirus Infections Diagnosis Cytomegalovirus Infections Radiography Magnetic Resonance Imaging Abnormalities Umbilical Cord Fetal Blood Human Descriptive Statistics Data Analysis Software Fisher's Exact Test DNA Male Female Infant, Newborn Infant Infant, Newborn: birth-1 month Infant: 1-23 months Male Female ab: Purpose: Brain MRI provides important information about suspected congenital CMV infection in neonatally underdiagnosed children. This study aimed to describe MRI findings in children in whom congenital CMV infection was not suspected during the neonatal period and was proven retrospectively. Methods: We enrolled 31 children referred to the pediatric neurology clinic with neurological symptoms who were proven to have congenital CMV infection based on dried umbilical cord samples. Upon diagnosis, MR and CT images were assessed using the van der Knaap scoring system integrated with additional variables. Two investigators independently assessed all images. Results: The age at diagnosis was < 12 months in 14, 12–24 months in 11, and > 24 months in 6 patients. The initial symptom triggering clinic referral was delayed development in 22, seizure in 5, deafness in 3, and hemiplegia in 1 patient. Of the 31 children, 30 had a white matter (WM) abnormality predominant in the deep WM of the parietal lobe (n = 25). Anterior temporal lesions were observed in 21 children. Cortical lesions were observed in 7 children, suggestive of polymicrogyria. No child had cerebellar or brainstem abnormalities. Brain CT was performed in 22 of 31 children, and 11 showed punctate cerebral calcification in the periventricular and/or deep WM. Conclusion: Patients with congenital CMV infection with delayed neurological symptoms show a relatively uniform pattern of parietal-dominant multifocal WM lesions and anterior temporal lesions, with or without polymicrogyria. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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