Hyperconnection and hyperperfusion of overlapping brain regions in patients with menstrual-related migraine: a multimodal neuroimaging study.
Purpose: Menstrual-related migraine (MRM) results in moderate to severe intensity headaches accompanied by physical and emotional disability over time in women. Neuroimaging methodologies have advanced our understanding of migraine; however, the neural mechanisms of MRM are not clearly understood. M...
| Published in: | Neuroradiology Vol. 63; no. 5; pp. 741 - 750 |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | diagnostic images research tables/charts Journal Article |
| Published: |
Springer Nature
May2021
|
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=149789432&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 149789432 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: May2021 vid: 63 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 149789432 147896213 149789432 149789432 10.1007/s00234-020-02623-5 149789432 ppf: 741 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Hyperconnection and hyperperfusion of overlapping brain regions in patients with menstrual-related migraine: a multimodal neuroimaging study. aug: au: Li, Xinyu Khan, Ahsan Li, Yingying Chen, Diansen Yang, Jing Zhan, Haohui Du, Ganqin Xu, Jin Lou, Wutao Tong, Raymond Kai-yu affil: Imaging Center, The First Affiliated Hospital, College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China sug: subj: Functional Connectivity Cerebrovascular Disorders Brain Physiopathology Menstruation Migraine Etiology Migraine Physiopathology Neuroradiography Human Female Magnetic Resonance Imaging Methods Menstrual Cycle Brain Mapping Cerebrovascular Circulation Evaluation Magnetic Resonance Angiography Descriptive Statistics Disease Duration Severity of Illness Chronic Pain Headache Emotions Women Neural Pathways Female ab: Purpose: Menstrual-related migraine (MRM) results in moderate to severe intensity headaches accompanied by physical and emotional disability over time in women. Neuroimaging methodologies have advanced our understanding of migraine; however, the neural mechanisms of MRM are not clearly understood. Methods: In this study, fourteen MRM patients in the interictal phase and fifteen age- and education-matched healthy control females were recruited. Resting-state functional magnetic resonance imaging (fMRI) and pulsed arterial spin labeling (PASL) MRI were collected for both the subject groups outside of their menstrual periods. Eigenvector centrality mapping (ECM) was performed on resting-state fMRI, and the relative cerebral blood flow (relCBF) was assessed using PASL-MRI. Results: MRM patients showed a significantly increased eigenvector centrality in the right medial frontal gyrus compared to healthy controls. Seed-based ECM analysis revealed that increased centrality was associated with the right medial frontal gyrus's hyperconnectivity with the left insula and the right supplementary motor area. The perfusion MRI revealed significantly increased relCBF in the hyperconnected regions. Furthermore, the hyperconnection positively correlated with the attack frequency, while the hyperperfusion showed a positive correlation with the disease duration. Conclusion: The results suggest that menstrual-related migraine is associated with cerebral hyperconnection and hyperperfusion in critical pain-processing brain regions. Furthermore, this elevated cerebral activity is correlated with different aspects of functional impairment in MRM patients suggesting that perfusion analysis, along with whole-brain connectivity analysis, can provide a comprehensive understanding of neural mechanisms of MRM. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|