Novel preclinical method for evaluating the efficacy of a percutaneous treatment in human ex vivo calcified plaque.
The lack of suitable atherosclerotic calcification models and testing strategies inhibits preclinical efficacy testing of existing and novel percutaneous devices. The goal of this study is to develop a preclinical testing method for quantitatively and qualitatively evaluating the efficacy of noncomp...
| Published in: | Medical & Biological Engineering & Computing Vol. 59; no. 4; pp. 799 - 812 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Published: |
Springer Nature
Apr2021
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=149884710&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 149884710 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: Apr2021 vid: 59 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 149884710 149235357 149884710 NLM33710527 10.1007/s11517-021-02334-w NLM33710527 149884710 ppf: 799 ppct: 13 formats: fmt: @attributes: type: P tig: atl: Novel preclinical method for evaluating the efficacy of a percutaneous treatment in human ex vivo calcified plaque. aug: au: Chisena, Robert S. Sengenberger, Jordan Shih, Albert J. Gurm, Hitinder affil: Department of Mechanical Engineering, University of Michigan at Ann Arbor, 2350 Hayward St, 48109, Ann Arbor, MI, USA sug: subj: Atherosclerosis Angioplasty, Transluminal, Percutaneous Coronary Atherosclerosis Therapy Tomography, X-Ray Computed Lower Extremity ab: The lack of suitable atherosclerotic calcification models and testing strategies inhibits preclinical efficacy testing of existing and novel percutaneous devices. The goal of this study is to develop a preclinical testing method for quantitatively and qualitatively evaluating the efficacy of noncompliant balloon angioplasty (NC BA) treatment in human ex vivo calcified plaque (CP). NC BA using a 3- and 4-mm diameter balloon was performed on an ex vivo tibial calcified vessel obtained from an amputation. Three-dimensional microcomputed tomography (μ-CT) imaging was performed pre- and post-BA to compare crack density in the CP. Comparing the pre- and posttreatment three-dimensional μ-CT images showed a glass-like cracking that occurred in the CP due to the BA procedure. Expansion of the 3-mm balloon showed little tissue deformation and no CP cracking. Although expansion of the 4-mm balloon occurred nonuniformly along balloon length and across the perpendicular projections, the balloon generated cracking throughout the CP, which allowed the surrounding elastic tissue to be dilated. This combined X-ray microscopy and μ-CT technique is a useful preclinical tool for quantifying the efficacy of percutaneous treatments for CP. Because of its nondestructive nature, the CP structure can be visualized pre- and posttreatment to determine the treatment effect. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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