Pilot Executive Functioning Intervention in Epilepsy: Behavioral and Quality of Life Outcomes.

Objective: To examine changes in emotional and behavioral functioning and health-related quality of life (HRQOL) following a web-based executive functioning (EF) intervention open pilot trial (e.g., Epilepsy Journey) for adolescents with epilepsy.Methods: Adolescents with an established diagnosis of...

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Published in:Journal of Pediatric Psychology Vol. 46; no. 4; pp. 363 - 375
Main Authors: Modi, Avani C, Mara, Constance A, Schmidt, Matthew, Smith, Aimee W, Turnier, Luke, Wade, Shari L
Format: research tables/charts randomized controlled trial Journal Article
Published: Oxford University Press / USA May2021
Online Access:View this record in EBSCOhost
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      dt: May2021
      vid: 46
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      pub: Oxford University Press / USA
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        10.1093/jpepsy/jsaa119
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        149940886
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        atl: Pilot Executive Functioning Intervention in Epilepsy: Behavioral and Quality of Life Outcomes.
      aug:
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          Modi, Avani C
          Mara, Constance A
          Schmidt, Matthew
          Smith, Aimee W
          Turnier, Luke
          Wade, Shari L
        affil: Department of Pediatrics, Cincinnati Children's Hospital Medical Center
      sug:
        subj:
          Epilepsy Therapy
          Quality of Life
          Female
          Executive Function
          Memory, Short Term
          Human
          Male
          Adolescence
          Problem Solving
          Comparative Studies
          Multicenter Studies
          Randomized Controlled Trials
          Evaluation Research
          Validation Studies
          Adolescent: 13-18 years
          Female
          Male
      ab: Objective: To examine changes in emotional and behavioral functioning and health-related quality of life (HRQOL) following a web-based executive functioning (EF) intervention open pilot trial (e.g., Epilepsy Journey) for adolescents with epilepsy.Methods: Adolescents with an established diagnosis of epilepsy, EF deficits, and without developmental disorders participated in a single-arm trial of Epilepsy Journey. Epilepsy Journey is a gamified, online learning environment comprised of 10 learning modules targeting EF deficits (e.g., working memory, organization) and tailored to epilepsy with accompanying telehealth problem-solving sessions. Adolescents completed questionnaires assessing emotional and behavioral functioning and HRQOL at baseline, posttreatment, and 2 follow-ups . Longitudinal mixed models and logistic regression analyses were used for these secondary analyses.Results: 39 adolescents were recruited for Epilepsy Journey (Mage=15.3 years; 67% female; 87% White: Non-Hispanic; 39% experienced seizures in the past 3 months). Preliminary data indicate significant improvements in caregiver-reported Externalizing symptoms, Behavioral Symptom Index scores and Adaptive Skills from baseline to 5-month follow-up. Significant improvements were observed for caregiver-reported Mood/Behavior and self-reported Impact, Cognitive Functioning, Executive Functioning, and Sleep subscales of the PedsQL Epilepsy Module. Clinically significant improvements (e.g., clinical/at-risk to normative levels) in behavioral and quality of life domains were also noted.Conclusion: Epilepsy Journey appears to contribute to changes in emotional and behavioral functioning and HRQOL in adolescents with epilepsy. Given the proof of concept trial format of this study, an important future direction is to conduct a randomized controlled trial with a larger, generalizable cohort of adolescents with epilepsy.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        randomized controlled trial
        Journal Article
      ougenre: Article
    language: English
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