A recurrent ZSWIM7 mutation causes male infertility resulting from decreased meiotic recombination.
Study Question: Are mutations in the zinc finger SWIM domain-containing protein 7 gene (ZSWIM7) associated with human male infertility?Summary Answer: The homozygous frameshift mutation (c.231_232del) in ZSWIM7 causes decreased meiotic recombination, spermatogenesis arrest, and infertility in men.Wh...
| Publicado en: | Human Reproduction Vol. 36; no. 5; pp. 1436 - 1446 |
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| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Oxford University Press / USA
May2021
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| Acceso en línea: | Ver este registro en EBSCOhost |