First-week urine beta-2 microglobulin levels in term healthy neonates.
Background: Beta-2 microglobulin (β2mG) is a low-molecular-weight protein that is almost exclusively eliminated through the kidneys. It is freely filtered in the glomeruli and almost completely reabsorbed and degraded in the proximal tubules. Normal urinary β2mG levels are very low (between 0.04 and...
| Publicado en: | Pediatric Nephrology Vol. 36; no. 6; pp. 1511 - 1515 |
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| Autores principales: | , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jun2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=150063540&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 150063540 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0931041X EF1 jtl: Pediatric Nephrology issn: 0931041X maglogo: N pubinfo: dt: Jun2021 vid: 36 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 150063540 147869739 150063540 150063540 10.1007/s00467-020-04839-2 150063540 ppf: 1511 ppct: 4 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: First-week urine beta-2 microglobulin levels in term healthy neonates. aug: au: Tzvi-Behr, Shimrit Ivgi, Heftziba Frishberg, Yaacov Ben Shalom, Efrat affil: Division of Pediatric Nephrology, Shaare Zedek Medical Center, Shmuel Bait Street 12, 9103102, Jerusalem, Israel sug: subj: Term Birth Serum Globulins Urine Neonatal Assessment Human Infant, Newborn Nephelometry and Turbidimetry Descriptive Statistics Confidence Intervals Male Female Infant, Newborn: birth-1 month Male Female ab: Background: Beta-2 microglobulin (β2mG) is a low-molecular-weight protein that is almost exclusively eliminated through the kidneys. It is freely filtered in the glomeruli and almost completely reabsorbed and degraded in the proximal tubules. Normal urinary β2mG levels are very low (between 0.04 and 0.22 mg/L). No reference values are known in infants and young children. Methods: Urinary β2mG levels were measured in 103 healthy term neonates during the first week of life by nephelometric technology. Results: The average level of urinary β2mG was 0.65 mg/L (95% confidence interval between 0 and 10.8 mg/L). There was a minor difference between male and female neonates but it did not reach statistical significance. There was no effect of the gestational week, birth weight, or weight loss in the first week of life, on urinary β2mG levels. Conclusions: First-week urinary β2mG levels in healthy term infants were higher than adult levels. Incomplete maturation of kidney tubules in neonates could be a possible explanation. These can now be used in clinical practice and further studies that assess the degree of proximal tubular function in health and disease. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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