Epidemiology changes in peptic ulcer diseases 18 years apart explored from the genetic aspects of Helicobacter pylori.
The prevalence of peptic ulcer diseases has decreased over the past decades. The contribution of Helicobacter pylori to these changes has not been clearly delineated. Two cohorts of patients receiving esophagogastroduodenoscopy examination together with urease test were enrolled, 1 from year 2001 (n...
| Publicado en: | Translational Research: The Journal of Laboratory & Clinical Medicine Vol. 232; pp. 115 - 121 |
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| Autores principales: | , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
Jun2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=150124010&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 150124010 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19315244 2Q66 jtl: Translational Research: The Journal of Laboratory & Clinical Medicine issn: 19315244 maglogo: N pubinfo: dt: Jun2021 vid: 232 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 150124010 150124010 NLM33352297 150124010 10.1016/j.trsl.2020.12.006 NLM33352297 150124010 ppf: 115 ppct: 6 formats: tig: atl: Epidemiology changes in peptic ulcer diseases 18 years apart explored from the genetic aspects of Helicobacter pylori. aug: au: Chen, Tsung-Hsing Cheng, Hao-Tsai Yeh, Chau-Ting affil: Department of Gastroenterology and Hepatology, Linkou Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan sug: subj: Helicobacter Pylori Helicobacter Infections Epidemiology Peptic Ulcer Epidemiology Peptic Ulcer Microbiology Peptic Ulcer Drug Therapy Human Female Male Duodenal Ulcer Drug Therapy Adult Middle Age Duodenal Ulcer Microbiology Aged Esterases Helicobacter Infections Microbiology Duodenal Ulcer Epidemiology Urease Proton Pump Inhibitors Therapeutic Use Genotype Polymorphism, Genetic Comparative Studies Multicenter Studies Evaluation Research Validation Studies Scales Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Female Male ab: The prevalence of peptic ulcer diseases has decreased over the past decades. The contribution of Helicobacter pylori to these changes has not been clearly delineated. Two cohorts of patients receiving esophagogastroduodenoscopy examination together with urease test were enrolled, 1 from year 2001 (n = 1030), the other from year 2019 (n = 600). The prevalence changes of peptic ulcer diseases as well as the associated clinical factors were analyzed. An independent cohort of gastric biopsy samples (n = 151) positive for H. pylori were retrieved for ureC gene genotype analysis. Comparison between the patients recruited from 2001 and 2019 revealed significant decrease in H. pylori infection (P < 0.001), duodenal ulcer prevalence (P < 0.001) and gastric ulcer prevalence (P < 0.001). Multivariate analysis showed that the decreases of these factors were independent (adjusted P < 0.001 for all). Intriguingly, in H. pylori positive patients, the prevalence of duodenal ulcer still decreased with year (P < 0.001), which was not found in gastric ulcer (P = 0.345). Genetic analysis of H. pylori urease gene showed that MboI-restriction fragment length polymorphism-defined genotype 3 UreC was significantly more prevalent in gastric ulcer patients than in others (P = 0.022). Independent decreases of H. pylori infection, gastric ulcer and duodenal ulcer over decades were found. In H. pylori positive patients, duodenal ulcer prevalence decreased overtime while gastric ulcer prevalence remained unchanged. Gastric ulcer/cancer had a higher prevalence of MboI-defined genotype 3 UreC gene. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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