Comparison of Liver Histopathology with Non-invasive Inflammation Markers as Neutrophil-lymphocyte Ratio, Platelet-lymphocyte Ratio and Mean Platelet Volume in Chronic Hepatitis B Patients.
Objectives: Platelet-lymphocyte ratio (PLR) and neutrophillymphocyte ratio (NLR) are commonly studied non-invasive inflammatory markers in cancer patients. There are some studies showing its association with fibrosis in patients with non-alcoholic steatohepatitis and chronic hepatitis B (CHB). The a...
| Publicado en: | Viral Hepatitis Journal / Viral Hepatit Dergisi Vol. 27; no. 1; pp. 1 - 6 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Galenos Yayinevi Tic. LTD. STI
Apr2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=150126958&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 150126958 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13079441 FSWQ jtl: Viral Hepatitis Journal / Viral Hepatit Dergisi issn: 13079441 maglogo: N pubinfo: dt: Apr2021 vid: 27 iid: 1 pid: 28155 pub: Galenos Yayinevi Tic. LTD. STI artinfo: ui: 150126958 150126958 150126958 10.4274/vhd.galenos.2021.2020-11-3 150126958 ppf: 1 ppct: 5 formats: fmt: @attributes: type: P tig: atl: Comparison of Liver Histopathology with Non-invasive Inflammation Markers as Neutrophil-lymphocyte Ratio, Platelet-lymphocyte Ratio and Mean Platelet Volume in Chronic Hepatitis B Patients. aug: au: Demiröz, Hakan Bayram, Mehmet Irak, Kader Yıldırım, Özgür Kumbasar, Abdulbaki Tabak, Ömür affil: University of Health Sciences Turkey, Kanuni Sultan Süleyman Training and Research Hospital, Clinic of Internal Medicine, İstanbul, Turkey sug: subj: Noninvasive Procedures Liver Cirrhosis Pathology Liver Cirrhosis Diagnosis Inflammation Biological Markers Blood Neutrophils Analysis Lymphocyte Count Platelet Count Mean Platelet Volume Viral Load Evaluation Hepatitis B, Chronic Physiopathology Human Inpatients Biopsy Retrospective Design Record Review Descriptive Statistics Blood Cell Count Sex Factors Hepatitis Viruses DNA Analysis ab: Objectives: Platelet-lymphocyte ratio (PLR) and neutrophillymphocyte ratio (NLR) are commonly studied non-invasive inflammatory markers in cancer patients. There are some studies showing its association with fibrosis in patients with non-alcoholic steatohepatitis and chronic hepatitis B (CHB). The aim of this study is to examine the relationship between liver histopathology and viral load parameters with NLR, PLR and mean platelet volume (MPV) in patients with CHB. Materials and Methods: Two hundred twenty-four CHB patients who admitted to our clinic between 2016 and 2019 and underwent liver biopsy were analysed retrospectively. Study data were obtained from patient files and electronic records. Results: The mean values in complete blood count were MPV: 10.39±1.114 fL, NLR: 2.093±1.048 and PLR: 106.228±37.451. The mean fibrosis score in liver biopsies was 1.38±1.07 and the histological activity index (HAI) was 5.88±2.27. There was a statistical significant relationship between MPV and fibrosis (r=0.244, p=0.005), HBV-DNA and HAI (r=0.296, p=0.001), HBV-DNA and fibrosis (r=0.278, p=0.001) in men. There was no statistical significant difference between the genders in terms of fibrosis scores and inflammatory parameters. Non-invasive markers didn't make a statistical significant difference according to HAI <6 and HAI ≥6, fibrosis <2 and fibrosis ≥2 and HBV-DNA <20,000 and HBV-DNA ≥20,000 (p>0.05). Conclusion: It has been determined that MPV may be a useful marker for predicting fibrosis in patients with CHB, but further studies are needed to replace liver biopsy. Continuous monitoring of MPV will contribute to disease surveillance. NLR and PLR weren't found to be an important marker for evaluating fibrosis. Amaç: Trombosit-lenfosit oranı (PLR) ve nötrofil-lenfosit oranı (NLR) kanser hastalarında yaygın araştırılan non-invaziv enflamasyon belirteçleri olup; non-alkolik steatohepatit ve kronik hepatit B'li (KHB) hastalarda fibrozis ile ilişkisini gösteren bazı çalışmalar bulunmaktadır. Amacımız, KHB'li hastalarda karaciğer histopatolojisi ve viral yük parametrelerinin; NLR, PLR ve ortalama trombosit hacmi (MPV) ile olan ilişkisini incelemektir. Gereç ve Yöntemler: İç hastalıkları ve gastroenteroloji polikliniğine 2016-2019 yılları arasında başvuran karaciğer biyopsisi yapılan 224 KHB hastası geriye dönük incelendi. Çalışma verileri, hasta dosyaları ve elektronik kayıtlardan elde edildi. Bulgular: Tam kan sayımında MPV: 10,39±1,114 fL, NLR: 2,093±1,048 ve PLR: 106,228±37,451 idi. Karaciğer biyopside fibrozis skoru: 1,38±1,07 ve histolojik aktivite indeksi (HAİ): 5,88±2,27 olarak saptandı. Erkeklerde MPV ile fibrozis arasında (r=0,244, p=0,005), HBV-DNA ve HAİ arasında (r=0,296, p=0,001), HBV-DNA ve fibrozis (r=0,278, p=0,001) arasında anlamlı bir ilişki saptanmıştır. İki grup arasında fibrozis skorları ve enflamatuvar parametreler açısından anlamlı farklılık gözlenmemiştir. HAİ <6 ve histolojik aktivite indeksi ≥6; fibrosis <2 ve fibrozisf ≥2 ve HBV-DNA <20.000 ve HBV-DNA ≥20.000 olma durumuna göre; non-invaziv belirteçler anlamlı bir farklılık oluşturmamıştır (p>0,05). Sonuç: KHB'li hastalarda MPV'nin fibrozis tahmin etmede yardımcı bir belirteç olabileceği, fakat karaciğer biyopsisi yerini tutabilmesi için ek çalışmaya gerek olduğu saptanmıştır. MPV'nin sürekli izlenmesi, hastalık sürveyansına katkıda bulunacaktır. NLR ve PLR fibrozisi değerlendirmede önemli bir belirteç olarak bulunmamıştır. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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