Combined application of DTI and BOLD-MRI in the assessment of renal injury with hyperuricemia.
Objective: To explore the value of combined diffusion tensor imaging (DTI) and blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) in detecting early renal alterations in patients with hyperuricemia. Materials and methods: Seventy-one individuals were enrolled in this study and d...
| Publicado en: | Abdominal Radiology Vol. 46; no. 4; pp. 1694 - 1703 |
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| Autores principales: | , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Apr2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=150129619&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 150129619 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: Apr2021 vid: 46 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 150129619 146505661 10.1007/s00261-020-02804-z 150129619 ppf: 1694 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Combined application of DTI and BOLD-MRI in the assessment of renal injury with hyperuricemia. aug: au: Cheng, Zhong-Yuan Lin, Qi-Ting Chen, Ping-Kang Si-Tu, Ding-Kun Qian, Long Feng, You-Zhen Cai, Xiang-Ran affil: Medical Imaging Center, First Affiliated Hospital of Jinan University, No. 613 West Huangpu Avenue, Tianhe District, 510630, Guangzhou, Guangdong, China sug: ab: Objective: To explore the value of combined diffusion tensor imaging (DTI) and blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) in detecting early renal alterations in patients with hyperuricemia. Materials and methods: Seventy-one individuals were enrolled in this study and divided into three groups according to their serum uric acid (SUA) level and clinical symptoms: healthy controls (HC, n = 23), asymptomatic hyperuricemia (AH, n = 22) and gouty arthritis (GA, n = 26). All patients underwent both DTI and BOLD-MRI examination. Renal cortical and medullary ADC, FA and R2* values were calculated, respectively, and compared among the three groups. Correlations between ADC, FA and R2* with estimated glomerular filtration rate (eGFR) and SUA in hyperuricemia were evaluated, respectively. Result: In the renal cortex, the ADC, FA and R2* values of the AH and GA groups were significantly lower than those of the HC groups (p < 0.05). In the renal medulla, the ADC and FA values in AH and GA patients were significantly lower than those in healthy controls (p < 0.05). The R2* value of the GA group significantly decreased, compared to that of the AH and HC groups (p < 0.05). SUA was negatively correlated with cortical ADC, FA and R2* values (p < 0.05) as well as with medullary ADC and FA values. No significant correlation was discovered between the eGFR and ADC, FA and R2* values. Conclusion: The combined evaluation of DTI and BOLD might provide a sensitive and non-invasive approach for detection of renal microstructural alterations and oxygen metabolism abnormality in hyperuricemia. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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