Causes behind error rates for predictive biomarker testing: the utility of sending post-EQA surveys.
External quality assessment (EQA) schemes assess the performance of predictive biomarker testing in lung and colorectal cancer and have previously demonstrated variable error rates. No information is currently available on the underlying causes of incorrect EQA results in the laboratories. Participa...
| Published in: | Virchows Archiv: European Journal of Pathology Vol. 478; no. 5; pp. 995 - 1007 |
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| Main Authors: | , , |
| Format: | Journal Article |
| Published: |
Springer Nature
May2021
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=150151741&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 150151741 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09456317 O1Z jtl: Virchows Archiv: European Journal of Pathology issn: 09456317 maglogo: N pubinfo: dt: May2021 vid: 478 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 150151741 147214554 150151741 NLM33225398 10.1007/s00428-020-02966-7 NLM33225398 150151741 ppf: 995 ppct: 12 formats: fmt: @attributes: type: P tig: atl: Causes behind error rates for predictive biomarker testing: the utility of sending post-EQA surveys. aug: au: Keppens, Cleo Schuuring, Ed Dequeker, Elisabeth M. C. affil: Department of Public Health and Primary Care, Biomedical Quality Assurance Research Unit, University of Leuven, box 7001, Kapucijnenvoer 35 block d, 1st floor, 3000, Leuven, Belgium sug: subj: In Situ Hybridization, Fluorescence Standards Lung Neoplasms Diagnosis Immunohistochemistry Standards Clinical Indicators Standards Colorectal Neoplasms Diagnosis Carcinoma, Non-Small-Cell Lung Diagnosis Reproducibility of Results Carcinoma, Non-Small-Cell Lung Pilot Studies Lung Neoplasms Colorectal Neoplasms Quality Improvement Standards Predictive Value of Tests Observer Bias Surveys Quality Assurance Standards Ferrans and Powers Quality of Life Index ab: External quality assessment (EQA) schemes assess the performance of predictive biomarker testing in lung and colorectal cancer and have previously demonstrated variable error rates. No information is currently available on the underlying causes of incorrect EQA results in the laboratories. Participants in EQA schemes by the European Society of Pathology between 2014 and 2018 for lung and colorectal cancer were contacted to complete a survey if they had at least one analysis error or test failure in the provided cases. Of the 791 surveys that were sent, 325 were completed including data from 185 unique laboratories on 514 incorrectly analyzed or failed cases. For the digital cases and immunohistochemistry, the majority of errors were interpretation-related. For fluorescence in situ hybridization, problems with the EQA materials were reported frequently. For variant analysis, the causes were mainly methodological for lung cancer but variable for colorectal cancer. Post-analytical (clerical and interpretation) errors were more likely detected after release of the EQA results compared to pre-analytical and analytical issues. Accredited laboratories encountered fewer reagent problems and more often responded to the survey. A recent change in test methodology resulted in method-related problems. Testing more samples annually introduced personnel errors and lead to a lower performance in future schemes. Participation to quality improvement projects is important to reduce deviating test results in laboratories, as the different error causes differently affect the test performance. EQA providers could benefit from requesting root cause analyses behind errors to offer even more tailored feedback, subschemes, and cases. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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