In Silico Structural, Functional, and Phylogenetic Analysis of Cytochrome (CYPD) Protein Family.
Cytochrome (CYP) enzymes catalyze the metabolic reactions of endogenous and exogenous compounds. The superfamily of enzymes is found across many organisms, regardless of type, except for plants. Information was gathered about CYP2D enzymes through protein sequences of humans and other organisms. The...
| Publicado en: | BioMed Research International pp. 1 - 14 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
5/10/2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=150228755&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 150228755 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 5/10/2021 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 150228755 150228755 150228755 10.1155/2021/5574789 150228755 ppf: 1 ppct: 13 formats: fmt: @attributes: type: P tig: atl: In Silico Structural, Functional, and Phylogenetic Analysis of Cytochrome (CYPD) Protein Family. aug: au: Ahmad, Hafiz Ishfaq Afzal, Gulnaz Jamal, Adil Kiran, Shumaila Khan, Musarrat Abbas Mehmood, Khalid Kamran, Zahid Ahmed, Irfan Ahmad, Shakeel Ahmad, Asmar Hussain, Javed Almas, Sadaf affil: Department of Animal Breeding and Genetics, University of Veterinary and Animal Sciences, Lahore, Pakistan sug: subj: Cytochrome P-450 Enzyme System Analysis Phylogenetics Human Animal Studies Immunity Cytochrome P-450 Enzyme System Metabolism Sequence Analysis Descriptive Statistics ab: Cytochrome (CYP) enzymes catalyze the metabolic reactions of endogenous and exogenous compounds. The superfamily of enzymes is found across many organisms, regardless of type, except for plants. Information was gathered about CYP2D enzymes through protein sequences of humans and other organisms. The secondary structure was predicted using the SOPMA. The structural and functional study of human CYP2D was conducted using ProtParam, SOPMA, Predotar 1.03, SignalP, TMHMM 2.0, and ExPASy. Most animals shared five central motifs according to motif analysis results. The tertiary structure of human CYP2D, as well as other animal species, was predicted by Phyre2. Human CYP2D proteins are heavily conserved across organisms, according to the findings. This indicates that they are descended from a single ancestor. They calculate the ratio of alpha-helices to extended strands to beta sheets to random coils. Most of the enzymes are alpha-helix, but small amounts of the random coil were also found. The data were obtained to provide us with a better understanding of mammalian proteins' functions and evolutionary relationships. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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