Assessing the whole-body protein synthetic response to feeding in human subjects.
All tissues are in a constant state of turnover, with a tightly controlled regulation of protein synthesis and breakdown rates. Due to the relative ease of sampling skeletal muscle tissue, basal muscle protein synthesis rates and the protein synthetic responses to various anabolic stimuli have been...
| Published in: | Proceedings of the Nutrition Society Vol. 80; no. 2; pp. 139 - 148 |
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| Main Authors: | , |
| Format: | research Journal Article |
| Published: |
Cambridge University Press
May2021
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=150317363&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 150317363 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00296651 29M jtl: Proceedings of the Nutrition Society issn: 00296651 maglogo: N pubinfo: dt: May2021 vid: 80 iid: 2 pid: 15979 pub: Cambridge University Press artinfo: ui: 150317363 150317363 NLM33399528 150317363 10.1017/S0029665120008009 NLM33399528 150317363 ppf: 139 ppct: 9 formats: tig: atl: Assessing the whole-body protein synthetic response to feeding in human subjects. aug: au: Trommelen, Jorn van Loon, Luc J. C. affil: NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre, Maastricht, the Netherlands sug: subj: Muscle Proteins Metabolism Amino Acids Metabolism Proteins Human Research Subjects Fasting Muscle, Skeletal Metabolism Comparative Studies Multicenter Studies Evaluation Research Validation Studies ab: All tissues are in a constant state of turnover, with a tightly controlled regulation of protein synthesis and breakdown rates. Due to the relative ease of sampling skeletal muscle tissue, basal muscle protein synthesis rates and the protein synthetic responses to various anabolic stimuli have been well defined in human subjects. In contrast, only limited data are available on tissue protein synthesis rates in other organs. Several organs such as the brain, liver and pancreas, show substantially higher (basal) protein synthesis rates when compared to skeletal muscle tissue. Such data suggest that these tissues may also possess a high level of plasticity. It remains to be determined whether protein synthesis rates in these tissues can be modulated by external stimuli. Whole-body protein synthesis rates are highly responsive to protein intake. As the contribution of muscle protein synthesis rates to whole-body protein synthesis rates is relatively small considering the large amount of muscle mass, this suggests that other organ tissues may also be responsive to (protein) feeding. Whole-body protein synthesis rates in the fasted or fed state can be quantified by measuring plasma amino acid kinetics, although this requires the production of intrinsically labelled protein. Protein intake requirements to maximise whole-body protein synthesis may also be determined by the indicator amino acid oxidation technique, but the technique does not allow the assessment of actual protein synthesis and breakdown rates. Both approaches have several other methodological and inferential limitations that will be discussed in detail in this paper. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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