The role of negative pressure wound therapy (NPWT) on the treatment of pyoderma gangrenosum: A systematic review and personal experience.
Pyoderma gangrenosum (PG) is a rare painful ulcerative neutrophilic inflammatory skin disease, necessitating a high level of diagnostic suspicion associated with appropriate treatment to avoid progression. Negative pressure wound therapy (NPWT) has been efficiently used in the treatment of different...
| Publicado en: | Wound Repair & Regeneration Vol. 29; no. 3; pp. 486 - 495 |
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| Autores principales: | , , , , , , , |
| Formato: | case study pictorial research systematic review tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
May2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=150339405&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 150339405 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10671927 DPV jtl: Wound Repair & Regeneration issn: 10671927 maglogo: Y pubinfo: dt: May2021 vid: 29 iid: 3 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 150339405 149485385 150339405 150339405 10.1111/wrr.12910 150339405 ppf: 486 ppct: 9 formats: fmt: @attributes: type: P tig: atl: The role of negative pressure wound therapy (NPWT) on the treatment of pyoderma gangrenosum: A systematic review and personal experience. aug: au: Almeida, Ivan R. Coltro, Pedro S. Gonçalves, Henrique O. C. Westin, Andrezza T. Almeida, Juliano B. Lima, Renan V. K. S. Silva, Marcelo F. Farina Junior, Jayme A. affil: Division of Plastic Surgery, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil sug: subj: Pyoderma Gangrenosum Therapy Negative Pressure Wound Therapy Treatment Outcomes Wound Healing Human Systematic Review Adult Female Pyoderma Gangrenosum Drug Therapy Immunosuppressive Agents Therapeutic Use Pyoderma Gangrenosum Surgery Surgical Flaps Combined Modality Therapy PubMed Medline Cochrane Library Adult: 19-44 years Female ab: Pyoderma gangrenosum (PG) is a rare painful ulcerative neutrophilic inflammatory skin disease, necessitating a high level of diagnostic suspicion associated with appropriate treatment to avoid progression. Negative pressure wound therapy (NPWT) has been efficiently used in the treatment of different types of wounds. However, the role of NPWT in the management of PG is still controversial, due to the risk of the pathergy phenomenon. In this article, we conducted a systematic review (according to the PRISMA guidelines) on the use of NPWT in the treatment of PG, and we report our personal experience with two patients treated with this device. The result of the review showed that articles on the topic are, in their entirety, of low levels of evidence, such as case series, case reports, and reviews. Improvement in wound healing with the use of NPWT was observed in 85.1% of the patients studied. Besides, a significant association between improvement in wound healing with NPWT and immunosuppressive therapy was observed. Regarding the cases reported here, both showed good outcomes with the use of NPWT and skin graft during the treatment of PG injuries. Due to the rarity of PG, there is a scarcity of studies with robust evidence for standardization and comparison between treatments, which consequently makes it difficult to select therapeutic options. However, based on this systematic review and reported cases, we consider NPWT a safe option for adjuvant treatment of wounds caused by PG if combined with systemic immunosuppression, which plays a key role in greater chances of successful treatment. This approach should be recommended, whenever possible, associated with skin grafting to accelerate wound closure. The role of negative pressure wound therapy (NPWT) on the treatment of pyoderma gangrenosum: a systematic review and personal experience. pubtype: Academic Journal doctype: case study pictorial research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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