Dietary intake of specific amino acids and liver status in subjects with nonalcoholic fatty liver disease: fatty liver in obesity (FLiO) study.
Purpose: Identification of dietary factors involved in the development and progression of nonalcoholic fatty liver disease (NAFLD) is relevant to the current epidemics of the disease. Dietary amino acids appear to play a key role in the onset and progression of NAFLD. The aim of this study was to an...
| Publicado en: | European Journal of Nutrition Vol. 60; no. 4; pp. 1769 - 1781 |
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| Autores principales: | , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jun2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=150416094&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 150416094 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Jun2021 vid: 60 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 150416094 150416094 150416094 10.1007/s00394-020-02370-6 150416094 ppf: 1769 ppct: 12 formats: fmt: @attributes: type: P tig: atl: Dietary intake of specific amino acids and liver status in subjects with nonalcoholic fatty liver disease: fatty liver in obesity (FLiO) study. aug: au: Galarregui, Cristina Cantero, Irene Marin-Alejandre, Bertha Araceli Monreal, J. Ignacio Elorz, Mariana Benito-Boillos, Alberto Herrero, José Ignacio de la O, Víctor Ruiz-Canela, Miguel Hermsdorff, Helen Hermana M. Bressan, Josefina Tur, Josep A. Martínez, J. Alfredo Zulet, M. Angeles Abete, Itziar affil: Department of Nutrition, Food Sciences and Physiology and Centre for Nutrition Research, Faculty of Pharmacy and Nutrition, University of Navarra, Irunlarrea 1, 31008, Pamplona, Spain sug: subj: Food Intake In Adulthood Amino Acids Adverse Effects Glucose Metabolism Liver Ultrasonography Health Status In Adulthood Obesity In Adulthood Nonalcoholic Fatty Liver Disease In Adulthood Human Adult Magnetic Resonance Imaging Biochemistry Descriptive Statistics Questionnaires Multiple Regression Models, Statistical Iron Ferritin Amino Acids, Branched-Chain Amino Acids, Sulfur Diabetes Mellitus, Type 2 Proteins Metabolism Adult: 19-44 years ab: Purpose: Identification of dietary factors involved in the development and progression of nonalcoholic fatty liver disease (NAFLD) is relevant to the current epidemics of the disease. Dietary amino acids appear to play a key role in the onset and progression of NAFLD. The aim of this study was to analyze potential associations between specific dietary amino acids and variables related to glucose metabolism and hepatic status in adults with overweight/obesity and NAFLD. Methods: One hundred and twelve individuals from the Fatty Liver in Obesity (FLiO) study were evaluated. Liver assessment was carried out by ultrasonography, magnetic resonance imaging and analysis of biochemical parameters. Dietary amino acid intake (aromatic amino acids (AAA); branched-chain amino acids (BCAA); sulfur amino acids (SAA)) was estimated by means of a validated 137-item food frequency questionnaire. Results: Higher consumption of these amino acids was associated with worse hepatic health. Multiple adjusted regression models confirmed that dietary AAA, BCAA and SAA were positively associated with liver fat content. AAA and BCAA were positively associated with liver iron concentration. Regarding ferritin levels, a positive association was found with BCAA. Dietary intake of these amino acids was positively correlated with glucose metabolism (glycated hemoglobin, triglyceride and glucose index) although the significance disappeared when potential confounders were included in the model. Conclusion: These findings suggest that the consumption of specific dietary amino acids might negatively impact on liver status and, to a lesser extent on glucose metabolism in subjects with overweight/obesity and NAFLD. A control of specific dietary amino acid composition should be considered in the management of NAFLD and associated insulin resistance. NCT03183193; June 2017. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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