The association of childhood trauma, lifetime stressful events and general psychopathological symptoms in euthymic bipolar patients and healthy subjects.
Background: Psychopathological symptoms during euthymia in Bipolar Disorder (BD) affect quality of life and predispose to the occurrence of new acute episodes, however only few studies investigated potential risk-factors. This study aims to explore the association between childhood trauma (CT), life...
| Published in: | Journal of Affective Disorders Vol. 289; pp. 66 - 74 |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , |
| Format: | research Journal Article |
| Published: |
Elsevier B.V.
Jun2021
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=150444808&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 150444808 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01650327 3M9 jtl: Journal of Affective Disorders issn: 01650327 maglogo: N pubinfo: dt: Jun2021 vid: 289 pid: 1004 pub: Elsevier B.V. artinfo: ui: 150444808 150444808 NLM33945916 150444808 10.1016/j.jad.2021.04.014 NLM33945916 150444808 ppf: 66 ppct: 8 formats: tig: atl: The association of childhood trauma, lifetime stressful events and general psychopathological symptoms in euthymic bipolar patients and healthy subjects. aug: au: Pedrini, Laura Ferrari, Clarissa Lanfredi, Mariangela Bellani, Marcella Porcelli, Stefano Caletti, Elisabetta Sala, Michela Rossetti, Maria Gloria Piccin, Sara Dusi, Nicola Balestrieri, Matteo Perlini, Cinzia Lazzaretti, Matteo Mandolini, Gian Mario Pigoni, Alessandro Boscutti, Andrea Bonivento, Carolina Serretti, Alessandro Rossi, Roberta Brambilla, Paolo affil: Unit of Psychiatry, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, via Pilastroni 4, 25125, Italy sug: subj: Bipolar Disorder Epidemiology Cross Sectional Studies Research Subjects Quality of Life Human Cyclothymic Disorder Comparative Studies Multicenter Studies Evaluation Research Validation Studies ab: Background: Psychopathological symptoms during euthymia in Bipolar Disorder (BD) affect quality of life and predispose to the occurrence of new acute episodes, however only few studies investigated potential risk-factors. This study aims to explore the association between childhood trauma (CT), lifetime stressful events (SLEs) and psychopathological symptoms in BD patients during euthymia and controls (HC).Methods: A total of 261 participants (93 euthymic patients with BD, 168 HC) were enrolled. Generalized linear models and multiple logistic models were used to assess the association among the Symptom Check List-90-R (SCL-90-R), the Infancy Trauma Interview, the Paykel Life Events Scale.Results: The rate of participants reporting CT was higher in BD (n=47; 53%) than HC (n=43; 30%) (p=0.001). The experience of neglect was strongly related to BD (OR 6.5; p=0.003). CT was associated to higher scores on the SCL-90-R subscales (all the subscales except Phobia). No effects of the interaction between CT and diagnosis were found on SCL-90-R. Finally, there was a main effect of CT on lifetime SLEs (p<.001), that was not associated with diagnosis (p=0.833), nor with the interaction between CT and diagnosis (p=0.624).Limitations: The cross-sectional design does not allow causal inferences; the exclusion of subjects reporting medical or psychiatric comorbidity limits generalizability.Conclusions: CT was associated both to psychopathological symptoms during euthymia and the lifetime SLEs, thus it may represent a vulnerability factor influencing the course of BD. Overall, these data contribute to overcome the limited evidences documenting the influence of environmental factors on euthymic phase in BD. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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