Similar but different: distinguishing between pemphigus vegetans and pyostomatitis-pyodermatitis vegetans.
A 51-year-old woman presented with a 4-month history of painful ulcers in the mouth and vulva, and painful vegetative plaques at intertriginous sites. Skin biopsies showed squamous hyperplasia and intraepidermal eosinophilic pustulation. Skin direct immunofluorescence (DIF) revealed intercellular de...
| Publicado en: | BMJ Case Reports Vol. 14; no. 4; pp. 1 - 4 |
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| Autores principales: | , , |
| Formato: | Journal Article |
| Publicado: |
BMJ Publishing Group
Apr2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=150456528&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 150456528 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1757790X B755 jtl: BMJ Case Reports issn: 1757790X maglogo: N pubinfo: dt: Apr2021 vid: 14 iid: 4 pid: 8280 pub: BMJ Publishing Group artinfo: ui: 150456528 10.1136/bcr-2021-242162 150456528 ppf: 1 ppct: 3 formats: tig: atl: Similar but different: distinguishing between pemphigus vegetans and pyostomatitis-pyodermatitis vegetans. aug: au: Stagg, Brendan Simpson, Anna Sidhu, Shireen affil: SA Health, Adelaide, South Australia, Australia. sug: ab: A 51-year-old woman presented with a 4-month history of painful ulcers in the mouth and vulva, and painful vegetative plaques at intertriginous sites. Skin biopsies showed squamous hyperplasia and intraepidermal eosinophilic pustulation. Skin direct immunofluorescence (DIF) revealed intercellular deposition of IgG and C3 in the lower part of the epidermis, while serum indirect immunofluorescence (IIF) confirmed the presence of antiepithelial antibodies. The patient was diagnosed with pemphigus vegetans, and successfully treated with dapsone, prednisolone and topical steroids. Although pemphigus vegetans and pyostomatitispyodermatitis vegetans can show identical clinical and histological features, the presence or absence of comorbid inflammatory bowel disease, and the results of both skin DIF and serum IIF can be used to distinguish between these two conditions. This case report explores the challenges in making this distinction, and the implications of establishing the correct diagnosis. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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