Impact of emollient therapy for preterm infants in the neonatal period on child neurodevelopment in Bangladesh: an observational cohort study.
Background: Topical treatment with sunflower seed oil (SSO) or Aquaphor® reduced sepsis and neonatal mortality in hospitalized preterm infants <33 weeks' gestational age in Bangladesh. We sought to determine whether the emollient treatments improved neurodevelopmental outcomes during early childhood...
| Published in: | Journal of Health, Population & Nutrition Vol. 40; no. 1; pp. 1 - 11 |
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| Main Authors: | , , , , , , , , , |
| Format: | research Journal Article |
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BioMed Central
5/26/2021
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=150519169&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 150519169 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16060997 HII jtl: Journal of Health, Population & Nutrition issn: 16060997 maglogo: N pubinfo: dt: 5/26/2021 vid: 40 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 150519169 150519169 NLM34039435 150519169 10.1186/s41043-021-00248-9 NLM34039435 150519169 ppf: 1 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Impact of emollient therapy for preterm infants in the neonatal period on child neurodevelopment in Bangladesh: an observational cohort study. aug: au: Darmstadt, Gary L. Khan, Naila Z. Rosenstock, Summer Muslima, Humaira Parveen, Monowara Mahmood, Wajeeha Ahmed, A. S. M. Nawshad Uddin Chowdhury, M. A. K. Azad Zeger, Scott Saha, Samir K. affil: Prematurity Research Center, Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, 1701 Page Mill Road, 94304, Palo Alto, CA, USA sug: subj: Emollients Therapeutic Use Infant, Premature Infant, Newborn Infant, Very Low Birth Weight Child, Preschool Prospective Studies Child Infant Bangladesh Child Development Human Comparative Studies Multicenter Studies Evaluation Research Validation Studies Scales Infant, Newborn: birth-1 month Child, Preschool: 2-5 years Child: 6-12 years Infant: 1-23 months ab: Background: Topical treatment with sunflower seed oil (SSO) or Aquaphor® reduced sepsis and neonatal mortality in hospitalized preterm infants <33 weeks' gestational age in Bangladesh. We sought to determine whether the emollient treatments improved neurodevelopmental outcomes during early childhood.Methods: 497 infants were randomized to receive SSO, Aquaphor®, or neither through the neonatal period or hospital discharge. 159 infant survivors were enrolled in the longitudinal follow-up study using a validated Rapid Neurodevelopmental Assessment tool and the Bayley Scales of Infant Development II (BSID II) administered at three-monthly intervals for the first year and thereafter at six-monthly intervals. Lowess smoothing was used to display neurodevelopmental status across multiple domains by age and treatment group, and Generalized Estimating Equations (GEE) were used to compare treatment groups across age points.Results: 123 children completed at least one follow-up visit. Lowess graphs suggest that lower proportions of children who received massage with either SSO or Aquaphor® had neurodevelopmental delays than control infants in a composite outcome of disabilities. In GEE analysis, infants receiving SSO showed a significant protective effect on the development of fine motor skills [odds ratio (OR) 0.92, 95% confidence interval (CI) 0.86-0.98, p=0.006]. The Psychomotor Development Index (PDI) in the BSID II showed significantly lower disability rates in the Aquaphor group (23.6%) compared to the control (55.2%) (OR 0.21, 95% CI 0.06-0.72, p=0.004).Conclusions: Emollient massage of very preterm, hospitalized newborn infants improved some child neurodevelopmental outcomes over the first 2 years of follow-up. Findings warrant further confirmatory research.Trial Registration: ClinicalTrials.gov (98-04-21-03-2) under weblink https://clinicaltrials.gov/ct2/show/NCT00162747. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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