A preliminary study on the characteristics of Th1/Th2 immune response in cerebrospinal fluid of AIDS patients with cryptococcal meningitis.
Background: Cryptococcal Meningitis (CM) is a common opportunistic infection in the late stage of acquired immunodeficiency syndrome (AIDS). Despite the wide use of effective antiretroviral and antifungal therapy in AIDS patients, CM is still a major morbidity and mortality cause. Understanding the...
| Publicado en: | BMC Infectious Diseases Vol. 21; no. 1; pp. 1 - 11 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
BioMed Central
5/29/2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=150576557&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 150576557 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14712334 1CHU jtl: BMC Infectious Diseases issn: 14712334 maglogo: N pubinfo: dt: 5/29/2021 vid: 21 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 150576557 150576557 NLM34051748 10.1186/s12879-021-06138-z NLM34051748 150576557 ppf: 1 ppct: 10 formats: tig: atl: A preliminary study on the characteristics of Th1/Th2 immune response in cerebrospinal fluid of AIDS patients with cryptococcal meningitis. aug: au: Li, Aixin Zhu, Wenjiao Yin, Jiming Huang, Xiaojie Sun, Lijun Hua, Wei Wang, Wen Zhang, Tong Dai, Lili Wu, Hao affil: Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, 100069, Beijing, China sug: subj: Cytokines Cerebrospinal Fluid Acquired Immunodeficiency Syndrome Immunology Meningitis, Cryptococcal Immunology Meningitis, Cryptococcal Cerebrospinal Fluid Female Biochemistry Immunity, Cellular Comorbidity Acquired Immunodeficiency Syndrome Microbiology Cryptococcus Acquired Immunodeficiency Syndrome Complications Cytokines Immunology Meningitis, Cryptococcal Complications Prospective Studies Middle Age Male Adult Vascular Endothelial Growth Factor A Middle Aged: 45-64 years Adult: 19-44 years Female Male ab: Background: Cryptococcal Meningitis (CM) is a common opportunistic infection in the late stage of acquired immunodeficiency syndrome (AIDS). Despite the wide use of effective antiretroviral and antifungal therapy in AIDS patients, CM is still a major morbidity and mortality cause. Understanding the immune response in cryptococcal infection may help to improve the treatment strategies.Methods: We established a prospective cohort of twelve AIDS patients with CM (HIV + CM+) admitted to the hospital from 2019 to 2020. All patients were examined at the baseline, 2 weeks, and 4 weeks thereafter. The level of 19 cytokines in cerebrospinal fluid (CSF) were recorded to analyze the characteristics and dynamic changes of Th1/Th2 immune response. Meanwhile, six AIDS patients without CM (HIV + CM-) and seventeen healthy subjects (HIV-CM-) were included as control groups for CSF assessment.Results: The HIV+ CM+ group had higher CSF IFN-γ, TNF-α, IL-6, IL-7, IL-8, IL-10, IL-12 (P40), IL-15, IL-18, CCL2 levels but lower IL-4 when compared with the HIV-CM- group at baseline. And they also had a higher level of IL-12 (P40) and IL-17A compared with HIV + CM- patients. Except one patient dropped out of the study, eleven HIV + CM+ patients received induction antifungal therapy and regular CSF testing, and the mortality rate was 9.1% (1/11) and 18.2% (2/11) respectively at week 2 and week 4. Compared with baseline CSF cytokines, IL-2, IL-13, IL-17A, and VEGF-A decreased in week 2, and the VEGF-A levels further decreased in week 4. But there was no difference in the levels of all cytokines between survivors and the dead.Conclusion: No evidence of Th1/Th2 imbalance was found in AIDS patients with CM. However, the CSF cytokine network may provide new clues for the treatment of AIDS patients with CM.Trial Registration: This trial was prospectively registered in 2019.7.16. The registered number is ChiCTR1900024565 . pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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