Bone Morphogenic Protein Signaling and Melanoma.
Opinion Statement: Malignant melanoma is a deadly form of skin cancer caused by neoplastic transformation of melanocytic cells. Despite recent progress in melanoma therapy, by inhibition of activated oncogenes or immunotherapy, survival rate for metastatic melanoma patients remains low. The remarkab...
| Publicado en: | Current Treatment Options in Oncology Vol. 22; no. 6; pp. 1 - 13 |
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| Autor principal: | |
| Formato: | review Journal Article |
| Publicado: |
Springer Nature
Jun2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=150637750&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 150637750 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15272729 3KHC jtl: Current Treatment Options in Oncology issn: 15272729 maglogo: N pubinfo: dt: Jun2021 vid: 22 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 150637750 150637750 NLM33866453 150637750 10.1007/s11864-021-00849-w NLM33866453 150637750 ppf: 1 ppct: 12 formats: fmt: @attributes: type: P tig: atl: Bone Morphogenic Protein Signaling and Melanoma. aug: au: Kraj, Piotr affil: Department of Biological Sciences, Old Dominion University, Mills Godwin Building, 5115 Hampton Blvd, 23529, Norfolk, VA, USA sug: subj: Bone Morphogenetic Proteins Physiology Melanoma Etiology Skin Neoplasms Etiology Skin Neoplasms Pathology Cell Transformation, Neoplastic Melanoma Pathology Signal Transduction Physiology Scales ab: Opinion Statement: Malignant melanoma is a deadly form of skin cancer caused by neoplastic transformation of melanocytic cells. Despite recent progress in melanoma therapy, by inhibition of activated oncogenes or immunotherapy, survival rate for metastatic melanoma patients remains low. The remarkable phenotypic plasticity of melanoma cells allows for rapid development of invasive properties and metastatic tumors, the main cause of mortality in melanoma patients. Phenotypic and molecular analyses of developing tumors revealed that epithelial-mesenchymal transition (EMT), a cellular and molecular mechanism, controls transition from mature melanocyte to less differentiated melanocyte lineage progenitor cells forming melanoma tumors. This transition is facilitated by persistence of transcriptional regulatory circuit characteristic of embryonic stage in mature melanocytes. Switching of the developmental program of mature melanocyte to EMT is induced by accumulated mutations, especially targeting BRAF, N-RAS, or MEK1/2 signaling pathways, and further promoted by dynamic stimuli from local environment including hypoxia, interactions with extracellular matrix and growth factors or cytokines. Recent reports demonstrate that signaling mediated by transforming growth factor-β (TGF-β) and bone morphogenic proteins (BMPs) play critical roles in inducing EMT by controlling expression of critical transcription factors. BMPs are essential modulators of differentiation, proliferation, apoptosis, invasiveness, and metastases in developing melanoma tumors. They control transcription and epigenetic landscape of melanoma cells. Better understanding of the role of BMPs may lead to new strategies to control EMT processes in melanocyte cell lineage and to achieve clinical benefits for the patients. pubtype: Academic Journal doctype: review Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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