Phenolic, flavonoid content and radical scavenging activity of Smilax china with its inhibitory potential against clinically important enzymes.
Smilax china (SC) is a medicinal plant that has been traditionally used for a number of pathological disorders. In current study, its various fractions were assessed for radical scavenging, phenolic, flavonoid content and enzyme inhibition. The methanolic extract (MSC) of SC was subjected to fractio...
| Publicado en: | Natural Product Research Vol. 35; no. 12; pp. 2066 - 2072 |
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| Autores principales: | , , , |
| Formato: | Journal Article |
| Publicado: |
Taylor & Francis Ltd
Jun2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=150769293&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 150769293 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14786419 RFT jtl: Natural Product Research issn: 14786419 maglogo: Y pubinfo: dt: Jun2021 vid: 35 iid: 12 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 150769293 10.1080/14786419.2019.1648463 150769293 ppf: 2066 ppct: 6 formats: tig: atl: Phenolic, flavonoid content and radical scavenging activity of Smilax china with its inhibitory potential against clinically important enzymes. aug: au: Ahmad, Hafiz Ibtesam Shoaib Khan, Haji Muhammad Akhtar, Naveed Ijaz, Shakeel affil: Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Punjab, Pakistan sug: ab: Smilax china (SC) is a medicinal plant that has been traditionally used for a number of pathological disorders. In current study, its various fractions were assessed for radical scavenging, phenolic, flavonoid content and enzyme inhibition. The methanolic extract (MSC) of SC was subjected to fractionation using different solvents including n-hexane, benzene, chloroform, ethyl acetate and n-butanol. Results revealed that ethyl acetate fraction showed maximum phenolic (101.81 ± 0.13 mg GAE/g) and flavonoid (96.80 ± 0.39 mg QE/g) content with maximum radical scavenging potential (82.51 ± 0.18%, IC50=104.45 µg/ml) as well as urease (82.63 ± 0.79%), tyrosinase (81.30 ± 0.41%) and Butyrylcholinesterase (BChE) (62.47 ± 0.76%) inhibition at 0.5 mg/ml. Whereas, maximum α-Glucosidase (87.56 ± 0.13%) and Acetylcholinesterase (AChE) inhibition (82.34 ± 0.64%) was exhibited by n-hexane and benzene fractions, respectively. Present study has revealed the promising radical scavenging, phenolic, flavonoid and enzyme inhibitory potential of various fractions of SC extract. Thus, the study is a step forward towards evidence-based phyto-medicine. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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