Autonomic and Electrophysiological Evidence for Reduced Auditory Habituation in Autism.

It is estimated that nearly 90% of children on the autism spectrum exhibit sensory atypicalities. What aspects of sensory processing are affected in autism? Although sensory processing can be studied along multiple dimensions, two of the most basic ones involve examining instantaneous sensory respon...

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Publicado en:Journal of Autism & Developmental Disorders Vol. 51; no. 7; pp. 2218 - 2229
Autores principales: Gandhi, Tapan K., Tsourides, Kleovoulos, Singhal, Nidhi, Cardinaux, Annie, Jamal, Wasifa, Pantazis, Dimitrios, Kjelgaard, Margaret, Sinha, Pawan
Formato: research tables/charts Journal Article
Publicado: Springer Nature Jul2021
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Jul2021
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      pub: Springer Nature
      place: New York, New York
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        10.1007/s10803-020-04636-8
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          Gandhi, Tapan K.
          Tsourides, Kleovoulos
          Singhal, Nidhi
          Cardinaux, Annie
          Jamal, Wasifa
          Pantazis, Dimitrios
          Kjelgaard, Margaret
          Sinha, Pawan
        affil: Department of Electrical Engineering, India Institute of Technology, 110016, New Delhi, India
      sug:
        subj:
          Auditory Perception
          Autism Spectrum Disorder
          Autonomic Nervous System
          Electrophysiology
          Human
          Sensation Disorders Risk Factors
          Skin Physiology
          Diagnosis, Neurologic
          Young Adult
          Adolescence
          Adolescent: 13-18 years
      ab: It is estimated that nearly 90% of children on the autism spectrum exhibit sensory atypicalities. What aspects of sensory processing are affected in autism? Although sensory processing can be studied along multiple dimensions, two of the most basic ones involve examining instantaneous sensory responses and how the responses change over time. These correspond to the dimensions of 'sensitivity' and 'habituation'. Results thus far have indicated that autistic individuals do not differ systematically from controls in sensory acuity/sensitivity. However, data from studies of habituation have been equivocal. We have studied habituation in autism using two measures: galvanic skin response (GSR) and magneto-encephalography (MEG). We report data from two independent studies. The first study, was conducted with 13 autistic and 13 age-matched neurotypical young adults and used GSR to assess response to an extended metronomic sequence. The second study involved 24 participants (12 with an ASD diagnosis), different from those in study 1, spanning the pre-adolescent to young adult age range, and used MEG. Both studies reveal consistent patterns of reduced habituation in autistic participants. These results suggest that autism, through mechanisms that are yet to be elucidated, compromises a fundamental aspect of sensory processing, at least in the auditory domain. We discuss the implications for understanding sensory hypersensitivities, a hallmark phenotypic feature of autism, recently proposed theoretical accounts, and potential relevance for early detection of risk for autism.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
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      ougenre: Article
    language: English
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