Aloe vera and Honey Solution and Their Ethanolic Extraction Solution Could Act on Metastasis-Regulating Processes in Walker 256 Tumor Tissues In Vivo?
Research has shown that both Aloe vera and honey have anticancer and nutrition properties, including the inhibition of metastasis. In order to evaluate the effect of a solution of Aloe vera and honey (A) and their ethanolic fraction (F) on metastasis-regulating processes in primary tumors, Wistar ra...
| Publicado en: | Nutrition & Cancer Vol. 73; no. 7; pp. 1244 - 1253 |
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| Autores principales: | , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=150797808&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 150797808 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: 2021 vid: 73 iid: 7 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 150797808 145550916 150797808 150797808 10.1080/01635581.2020.1784443 150797808 ppf: 1244 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Aloe vera and Honey Solution and Their Ethanolic Extraction Solution Could Act on Metastasis-Regulating Processes in Walker 256 Tumor Tissues In Vivo? aug: au: Tomasin, Rebeka Pascoal, Aislan Cristina Rheder Fagundes Salvador, Marcos José Gomes-Marcondes, Maria Cristina Cintra affil: Department of Structural and Functional Biology, Laboratory of Nutrition and Cancer, Institute of Biology, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil sug: subj: Breast Neoplasms Drug Therapy Neoplasm Metastasis Prevention and Control Aloe Pharmacodynamics Honey Therapeutic Use Antineoplastic Agents, Combined Pharmacodynamics Ethanol Pharmacodynamics Animal Studies Rats In Vivo Studies Antineoplastic Agents, Combined Administration and Dosage Aloe Administration and Dosage Glycoproteins Drug Effects Peptide Hydrolases Drug Effects Neovascularization, Pathologic Prevention and Control Chromatography, High Pressure Liquid Mass Spectrometry Epithelial-Mesenchymal Transition Drug Effects ab: Research has shown that both Aloe vera and honey have anticancer and nutrition properties, including the inhibition of metastasis. In order to evaluate the effect of a solution of Aloe vera and honey (A) and their ethanolic fraction (F) on metastasis-regulating processes in primary tumors, Wistar rats were subcutaneously implanted with Walker 256 tumors and treated with A and F (670 µl/kg by gavage, daily for 21 days). An analysis of the primary tumor tissues of these animals showed a decrease in N-cadherin expression in groups WA and WF, with a concomitant increase in E-cadherin expression in group WA compared to the control group. Cathepsin D activity was also decreased in the tumor tissues from groups WA and WF. In addition, the number of blood vessels and their diameter significantly reduced in tumor tissues from groups WA and WF compared to those from control group. UHPLC-ESI-MS/MS analysis of the samples A and F, suggested presence of molecules with verified antitumor activity, including caffeic acid, ferulic acid, mannose, aloin A, aloin B, pinocembrin, chrysin, and kaempferol. These data showed that treatment with A and F could reduce the metastatic propensity of tumors by modulating neoangiogenesis and the process of epithelial-to-mesenchymal transition. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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