Important Tools for Use by Pediatric Endocrinologists in the Assessment of Short Stature.

Assessment and management of children with growth failure has improved greatly over recent years. However, there remains a strong potential for further improvements by using novel digital techniques. A panel of experts discussed developments in digitalization of a number of important tools used by p...

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Publicado en:Journal of Clinical Research in Pediatric Endocrinology Vol. 13; no. 2; pp. 124 - 136
Autores principales: Labarta, José I., Ranke, Michael B., Maghnie, Mohamad, Martin, David, Guazzarotti, Laura, Pfäffle, Roland, Koledova, Ekaterina, Wit, Jan M.
Formato: review Journal Article
Publicado: Galenos Yayinevi Tic. LTD. STI Jun2021
Acceso en línea:Ver este registro en EBSCOhost
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      pub: Galenos Yayinevi Tic. LTD. STI
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        atl: Important Tools for Use by Pediatric Endocrinologists in the Assessment of Short Stature.
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        au:
          Labarta, José I.
          Ranke, Michael B.
          Maghnie, Mohamad
          Martin, David
          Guazzarotti, Laura
          Pfäffle, Roland
          Koledova, Ekaterina
          Wit, Jan M.
        affil: University of Zaragoza, Children's Hospital Miguel Servet, Instituto de Investigación Sanitaria de Aragón, Unit of Endocrinology, Zaragoza, Spain
      sug:
        subj:
          Pediatricians
          Endocrinologists
          Body Height Evaluation
          Prediction Models Utilization
          Growth Disorders Diagnosis
          Growth Disorders Risk Factors
          Risk Assessment
          Digital Technology
          Algorithms
          Sensitivity and Specificity
          Child Health
          Age Determination by Skeleton
          Human Growth Hormone Therapeutic Use
          Software
          Diffusion of Innovation
          Skull
          Deep Learning
          Neural Networks (Computer)
          Growth Disorders
          Treatment Outcomes Evaluation
          Artificial Intelligence
          Somatomedins Analysis
          Technology, Medical
          Quality Improvement
          Congresses and Conferences Italy
          Italy
          Human Growth Hormone Deficiency
      ab: Assessment and management of children with growth failure has improved greatly over recent years. However, there remains a strong potential for further improvements by using novel digital techniques. A panel of experts discussed developments in digitalization of a number of important tools used by pediatric endocrinologists at the third 360° European Meeting on Growth and Endocrine Disorders, funded by Merck KGaA, Germany, and this review is based on those discussions. It was reported that electronic monitoring and new algorithms have been devised that are providing more sensitive referral for short stature. In addition, computer programs have improved ways in which diagnoses are coded for use by various groups including healthcare providers and government health systems. Innovative cranial imaging techniques have been devised that are considered safer than using gadolinium contrast agents and are also more sensitive and accurate. Deep-learning neural networks are changing the way that bone age and bone health are assessed, which are more objective than standard methodologies. Models for prediction of growth response to growth hormone (GH) treatment are being improved by applying novel artificial intelligence methods that can identify non-linear and linear factors that relate to response, providing more accurate predictions. Determination and interpretation of insulin-like growth factor-1 (IGF-1) levels are becoming more standardized and consistent, for evaluation across different patient groups, and computer-learning models indicate that baseline IGF-1 standard deviation score is among the most important indicators of GH therapy response. While physicians involved in child growth and treatment of disorders resulting in growth failure need to be aware of, and keep abreast of, these latest developments, treatment decisions and management should continue to be based on clinical decisions. New digital technologies and advancements in the field should be aimed at improving clinical decisions, making greater standardization of assessment and facilitating patient-centered approaches.
      pubtype: Academic Journal
      doctype:
        review
        Journal Article
      ougenre: Article
    language: English
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