Autophagy in Gastric Mucosa: The Dual Role and Potential Therapeutic Target.
The incidence of stomach diseases is very high, which has a significant impact on human health. Damaged gastric mucosa is more vulnerable to injury, leading to bleeding and perforation, which eventually aggravates the primary disease. Therefore, the protection of gastric mucosa is crucial. However,...
| Publicado en: | BioMed Research International pp. 1 - 9 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | review tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
6/12/2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=150878376&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 150878376 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 6/12/2021 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 150878376 150878376 150878376 10.1155/2021/2648065 150878376 ppf: 1 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Autophagy in Gastric Mucosa: The Dual Role and Potential Therapeutic Target. aug: au: Lu, Sheng-Yu Guo, Song Chai, Shao-Bin Yang, Jia-Qi Yue, Yuan Li, Hao Sun, Pei-Ming Zhang, Tao Sun, Hong-Wei Zhou, Jin-Lian Yang, Jian-Wu Yang, He-Ming Li, Zheng-Peng Cui, Yan affil: Department of General Surgery, The 306th Hospital of PLA-Peking University Teaching Hospital, Beijing 100101, China sug: subj: Gastric Mucosa Physiopathology Autophagy Stomach Diseases Drug Therapy Gastric Mucosa Pathology Antiinflammatory Agents, Non-Steroidal Therapeutic Use Helicobacter Infections Drug Therapy ab: The incidence of stomach diseases is very high, which has a significant impact on human health. Damaged gastric mucosa is more vulnerable to injury, leading to bleeding and perforation, which eventually aggravates the primary disease. Therefore, the protection of gastric mucosa is crucial. However, existing drugs that protect gastric mucosa can cause nonnegligible side effects, such as hepatic inflammation, nephritis, hypoacidity, impotence, osteoporotic bone fracture, and hypergastrinemia. Autophagy, as a major intracellular lysosome-dependent degradation process, plays a key role in maintaining intracellular homeostasis and resisting environmental pressure, which may be a potential therapeutic target for protecting gastric mucosa. Recent studies have demonstrated that autophagy played a dual role when gastric mucosa exposed to biological and chemical factors. More indepth studies are needed on the protective effect of autophagy in gastric mucosa. In this review, we focus on the mechanisms and the dual role of various biological and chemical factors regulating autophagy, such as Helicobacter pylori, virus, and nonsteroidal anti-inflammatory drugs. And we summarize the pathophysiological properties and pharmacological strategies for the protection of gastric mucosa through autophagy. pubtype: Academic Journal doctype: review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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