Interobserver reproducibility of perineural invasion of prostatic adenocarcinoma in needle biopsies.
Numerous studies have shown a correlation between perineural invasion (PNI) in prostate biopsies and outcome. The reporting of PNI varies widely in the literature. While the interobserver variability of prostate cancer grading has been studied extensively, less is known regarding the reproducibility...
| Published in: | Virchows Archiv: European Journal of Pathology Vol. 478; no. 6; pp. 1109 - 1117 |
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| Main Authors: | , , , , , , , , , , |
| Format: | pictorial research tables/charts Journal Article |
| Published: |
Springer Nature
Jun2021
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=150893570&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 150893570 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09456317 O1Z jtl: Virchows Archiv: European Journal of Pathology issn: 09456317 maglogo: N pubinfo: dt: Jun2021 vid: 478 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 150893570 148466410 150893570 NLM33534005 150893570 10.1007/s00428-021-03039-z NLM33534005 150893570 ppf: 1109 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Interobserver reproducibility of perineural invasion of prostatic adenocarcinoma in needle biopsies. aug: au: Egevad, Lars Delahunt, Brett Samaratunga, Hemamali Tsuzuki, Toyonori Olsson, Henrik Ström, Peter Lindskog, Cecilia Häkkinen, Tomi Kartasalo, Kimmo Eklund, Martin Ruusuvuori, Pekka affil: Department of Oncology and Pathology, Karolinska Institutet, Karolinska University Hospital, Radiumhemmet P1:02, 171 76, Stockholm, Sweden sug: subj: Prostatic Neoplasms Pathology Prostate Pathology Neoplasm Invasiveness Pathology Adenocarcinoma Pathology Male Middle Age Aged Reproducibility of Results Immunohistochemistry Methods Biopsy Observer Bias Funding Source Middle Aged: 45-64 years Aged: 65+ years Male ab: Numerous studies have shown a correlation between perineural invasion (PNI) in prostate biopsies and outcome. The reporting of PNI varies widely in the literature. While the interobserver variability of prostate cancer grading has been studied extensively, less is known regarding the reproducibility of PNI. A total of 212 biopsy cores from a population-based screening trial were included in this study (106 with and 106 without PNI according to the original pathology reports). The glass slides were scanned and circulated among four pathologists with a special interest in urological pathology for assessment of PNI. Discordant cases were stained by immunohistochemistry for S-100 protein. PNI was diagnosed by all four observers in 34.0% of cases, while 41.5% were considered to be negative for PNI. In 24.5% of cases, there was a disagreement between the observers. The kappa for interobserver variability was 0.67-0.75 (mean 0.73). The observations from one participant were compared with data from the original reports, and a kappa for intraobserver variability of 0.87 was achieved. Based on immunohistochemical findings among discordant cases, 88.6% had PNI while 11.4% did not. The most common diagnostic pitfall was the presence of bundles of stroma or smooth muscle. It was noted in a few cases that collagenous micronodules could be mistaken for a nerve. The distance between cancer and nerve was another cause of disagreement. Although the results suggest that the reproducibility of PNI may be greater than that of prostate cancer grading, there is still a need for improvement and standardization. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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