The History of Human Subjects Research and Rationale for Institutional Review Board Oversight.

The history of human subjects research and the abuses that led to the creation of the United States' (US) regulatory schema for research, which includes institutional review boards (IRBs), is long and complex. However, when one understands the history, one can see direct links between those abuses a...

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Publicado en:Nutrition in Clinical Practice Vol. 36; no. 3; pp. 560 - 568
Autores principales: Spellecy, Ryan, Busse, Kristin
Formato: review tables/charts Journal Article
Publicado: Wiley-Blackwell Jun2021
Acceso en línea:Ver este registro en EBSCOhost
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        atl: The History of Human Subjects Research and Rationale for Institutional Review Board Oversight.
      aug:
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          Spellecy, Ryan
          Busse, Kristin
        affil: Center for Bioethics and Medical Humanities and Office of Research, Medical College of Wisconsin, Milwaukee Wisconsin,, USA
      sug:
        subj:
          Research, Medical History
          Research, Medical Ethical Issues
          Research Subjects History
          Institutional Review
          Protection of Human Subjects
          Research Ethics
          Consent (Research)
          Research, Medical Legislation and Jurisprudence
          Rules and Regulations
      ab: The history of human subjects research and the abuses that led to the creation of the United States' (US) regulatory schema for research, which includes institutional review boards (IRBs), is long and complex. However, when one understands the history, one can see direct links between those abuses and the regulations, as well as the ethical principles, contained in the Belmont Report. To that end, we provide a brief analysis of the history of human subjects research and its abuses, including a lesser known case (the atrocities committed by Nazi scientists and physicians during World War II) and infamous cases in the US (including the Tuskegee Syphilis Study and Willowbrook). With that history in hand, we will then seek to understand the regulations that govern human subjects research and the IRB by grounding them both in the ethical principles in the Belmont Report.
      pubtype: Academic Journal
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        review
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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